Medetomidine
Last updated: 07/08/2023
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Used as an antifouling substance in marine paint and as a general anaesthetic as a sedative and analgesic drug for a variety of animals.
Barnacles; Tube worms; Fungi; Algae
Paint
-
-
-
Not approved
Not applicable
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Not applicable
Not applicable
No
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
Isomeric. The biologically active dextroisomer of medetomidine is known as dexmedetomide
C₁₃H₁₆N₂
CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
-
CUHVIMMYOGQXCV-UHFFFAOYSA-N
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
medetomidine hydrochloride
Variant
Veterinary substance, Other substance
Biocide
Unclassified substance
>99%
-
Synthetic
A non-narcotic alpha2-adrenoreceptor agonist
86347-14-0
811-718-6
None allocated
-
69602
No data found
200.28
-
(RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole
-
-
-
Not applicable
Not applicable
Not applicable
Not applicable
-
White crystalline, odourless powder
19800
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
High
3300
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
p-Xylene
-
65000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Acetone
-
116
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
382
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
-
-
-
-
191.3
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
7.94 X 1002
Calculated
-
2.9
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
3.5 X 10-03
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low volatility
-
-
-
-
-
-
-
-
-
-
100
E2 E = Manufacturers safety data sheets 2 = Unverified data of unknown source
Persistent
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Literature: Slow degradation
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
110
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Slow
-
-
-
Soil adsorption and mobility
-
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Slightly mobile
2460
Literature data range Koc 1215 to 3705 g/mL
-
-
-
-
-
-
-
1.22
Calculated
Low leachability
2.77 X 10-02
Calculated
-
-
High
Calculated
-
Slightly mobile
Calculated
-
-
-
-
-
-
None
Terrestrial ecotoxicology
> 31.25
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
High
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
30.0
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Danio rerio
Moderate
-
-
-
4.5
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Moderate
-
-
-
0.005
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Americamysis bahia as 28 day NOEC
High
-
-
-
-
-
-
-
-
-
-
-
-
0.34
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Scenedesmus subspicatus
Moderate
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
> 31.25
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
High
2000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
-
0.14
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat 4 hr
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
EU MRL pesticide database 
-
-
-
-
-
-
-
Metabolised and excreted via the kidneys in the urine.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
Possible lungs, liver and kidney toxicant May cause hypersensitivity reactions Harmful if swallowed Has a strong sedative effect
Emits a variety of toxic fumes on combustion Corrosive Not explosive or oxidising
Health: H300, H310 Environment: H400, H410
Not listed (Not listed)
Not regulated
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-
medetomidine
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medetomidina
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Record last updated:
07/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242