Fluindapyr (Ref: IR9792)

Fluindapyr (Ref: IR9792)	Last updated: 01/10/2025
(Not known by any other names)

SUMMARY

Hazard alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.

Environmental fate	Ecotoxicity	Human health
Environmental fate High alert: Persistent; Potential for particle bound transport: High	Ecotoxicity Moderate alert: Fish acute ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Bees acute oral ecotoxicity: Moderate	Human health Low alert Warning: Significant data are missing

GENERAL INFORMATION

Description

Fluindapyr is a pesticide active ingredient that has been shown to be highly effective in controlling a broad range of plant diseases on various crops and also for non-cropping situations

Example pests controlled

Asian Soybean rust; Scab; Brown rot blossom blight; Leaf rust; Pink snow mold; Powdery mildew

Example applications

Soybean; Pecan nuts; Cereals; Almonds; Grapes & fruiting vines; Turfgrass; Ornamentals; Utility rights-of-way, roadsides, railways and industrial areas.

Efficacy & activity

GB regulatory status

GB COPR regulatory status

Not approved

Date COPR inclusion expires

Not applicable

GB LERAP status

No UK approval for use as a plant protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Pending

Dossier rapporteur/co-rapporteur

Date EC 1107/2009 inclusion expires

EU Candidate for substitution (CfS)

Not applicable

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
			✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Paraguay

Chemical structure

Isomerism

Fluindapyr exhibits stereoisomerism due to the presence of a chiral carbon atom in its molecular structure, specifically within the 1-fluoroethyl group attached to the pyrazole ring. This chiral centre results in two enantiomers, (R)- and (S)-fluindapyr. The commercial formulation of fluindapyr is typically supplied as a racemic mixture.

Chemical formula

C₁₈H₂₀F₃N₃O

Canonical SMILES

CC1CC(C)(C)c2c(ccc(c12)N=C(c3cn(C)nc3C(F)F)O)F

Isomeric SMILES

International Chemical Identifier key (InChIKey)

XCGBHLLWJZOLEM-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C18H20F3N3O/c1-9-7-18(2,3)14-11(19)5-6-12(13(9)14)22-17(25)10-8-24(4)23-15(10)16(20)21/h5-6,8-9,16H,7H2,1-4H3,(H,22,25)

2D structure diagram/image available?

Yes

General status

Pesticide type

Fungicide

Substance groups

Pyrazolecarboxamide fungicide; Carboxamide fungicide

Minimum active substance purity

Known relevant impurities

Substance origin

Synthetic

Mode of action

Broad-spectrum and systemic. Succinate Dehydrogenase Inhibitor (SDHI). Inhibits the energy production process in pathogenic fungi

CAS RN

1383809-87-7

EC number

800-189-7

CIPAC number

None allocated

US EPA chemical code

138008

PubChem CID

57343740

CLP index number

No data found

Molecular mass

351.37

PIN (Preferred Identification Name)

rac-3-(difluoromethyl)-N-[(3R)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide

IUPAC name

3-(difluoromethyl)-N-[(3RS)-7-fluoro-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide

CAS name

3-(difluoromethyl)-N-(7-fluoro-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide

Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

PFAS

Highly Hazardous Pesticide (HHP)

Other status information

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Examples of recorded resistance

Physical state

Off-white coloured solid

Commercial

Property

Value

Availability status

Novel

Introduction & key dates

2012, developed

Example manufacturers & suppliers of products using this active now or historically

Isagro S.p.A
FMC Corporation

Example products using this active

Adastrio
Kalida Fungicide SDS

Formulation and application details

Usually formulated as a suspension concentrate

Commercial production

Impact on climate of production and use

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

1.63

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

Melting point (°C)

169

Boiling point (°C)

Degradation point (°C)

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

1.32 X 10⁰⁴

Calculated

Log P

4.12

High

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

Vapour pressure at 20 °C (mPa)

2.85 X 10^-05

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

6.05 X 10^-11

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Surface tension (mN m⁻¹)

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

244

Persistent

DT₅₀ (lab at 20 °C)

244

Persistent

DT₅₀ (field)

DT₉₀ (lab at 20 °C)

838

Very persistent

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

US EPA data 2020: Lab studies DT₅₀ (normalised) range 144-353 days, DT₉₀ (normalised) range 478-1339 days, Soil=10

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable at all relevant pH values

Water-sediment DT₅₀ (days)

Water phase only DT₅₀ (days)

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

34.8

Slightly mobile

K_oc (mL g⁻¹)

1764

Notes and range

US EPA data 2020: K_d range 6.44-88.3 mL g⁻¹, K_oc range 1288-3302 mL g⁻¹, Soils=5

Freundlich

K_f (mL g⁻¹)

K_foc (mL g⁻¹)

¹/_n

Notes and range

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

1.80

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

6.32 X 10^-02

Calculated

Note

Potential for particle bound transport index

High

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

Bio-concentration factor

BCF (l kg⁻¹)

345

Threshold for concern

CT₅₀ (days)

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

(1R,3S)-4-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)-7-fluoro-1,3-dimethyl-2,3-dihydro-1H-indene-1-carboxylic acid (Ref: trans-1-carboxy-IR9792/F9990)

Major fraction

0.113

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (Ref: pyrazole-carboxamide)

Minor fraction

0.073

3-(difluoromethyl)-N-(7-fluoro-3-hydroxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide (Ref: 3-hydroxy-IR9792)

Major fraction

0.190

(1R,3R)-4-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)-7-fluoro-1,3-dimethyl-2,3-dihydro-1H-indene-1-carboxylic acid (Ref: cis-1-carboxy-IR9792/F9990)

Major fraction

0.128

Known groundwater metabolites

None

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

(1R,3S)-4-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)-7-fluoro-1,3-dimethyl-2,3-dihydro-1H-indene-1-carboxylic acid
Note: US EPA data

trans-1-carboxy-IR9792/F9990

Surface water

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
Note: US EPA data

pyrazole-carboxamide

Surface water

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Note: US EPA data

pyrazole-carboxylic acid

Surface water

3-(difluoromethyl)-N-(7-fluoro-3-hydroxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide
Note: US EPA data

3-hydroxy-IR9792

Surface water

>0.100

(1R,3R)-4-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)-7-fluoro-1,3-dimethyl-2,3-dihydro-1H-indene-1-carboxylic acid
Note: US EPA data

cis-1-carboxy-IR9792/F9990

Surface water

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2250

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

> 1000

Eisenia foetida

Low

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

Soil micro-organisms

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

Seedling emergence ER₅₀ (g ha⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 300

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 32.8

Moderate

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps)

Beneficial insects (Predatory mites)

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.121

Oncorhynchus mykiss

Moderate

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.414

Daphnia magna

Moderate

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹) (EC₅₀)

> 2.0

Lemna gibba

Moderate

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute (growth rate, fresh; mg l⁻¹) (EC₅₀)

> 4.83

Unknown species

Moderate

Algae - Chronic (growth rate, fresh; mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.19

Rat

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

Occupational

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

No data found

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

No information available

Handling issues

Property

Value and interpretation

General

IMDG Transport Hazard class 9

CLP classification 2013

Health: H302, H332

WHO Classification

Not listed (Not listed)

UN Number

UN3082

Waste disposal & packaging

Packaging group III (Minor danger)

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

fluindapyr

French

German

Danish

Italian

Spanish

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	01/10/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242