Diphacinone
Last updated: 16/01/2023
(Also known as: diphacin; diphenadione)
Diphacinone is an anticoagulant rodenticide. It has a low aqueous solubiltiy and a low volatility. It is not expected to be persistent in soils but may be in water systems depending on local conditions. Based on its physico-chemical properties, diphacinone is not expected to leach to groundwater. Ecotoxicological data is limited but diphacinone is moderately toxic to fish but less so to birds. This substance has a high mammalian oral toxicity and is an eye irritant.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An anticoagulant rodenticide
Rats; Mice; Voles; Squirrels; Other small rodents
Rats; Mice; Voles; Squirrels; Other small rodents
-
Current
circa 1952
Not approved
Expired
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Expired
-
Yes
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
None
C₂₃H₁₆O₃
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)C3C(=O)C4=CC=CC=C4C3=O
No data
JYGLAHSAISAEAL-UHFFFAOYSA-N
InChI=1S/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H
Yes
Rodenticide
Indandione rodenticide
-
-
Synthetic
Anti-coagulant with longer activity than warfarin
82-66-6
201-434-5
131
067701
6719
606-038-00-X
340.37
2-(diphenylacetyl)-1H-indene-1,3(2H)-dione
2-(diphenylacetyl)indan-1,3-dione
2-(diphenylacetyl)-1H-indene-1,3(2H)-dione
Marine Pollutant
-
Not applicable
Not applicable
Not applicable
Not applicable
-
Pale yellow powder
velsicol Bell laboratories
Ratindan Diphacine Ditrac Gold crest Kill-Ko Ramik
Available in a wide variety of formulations including meal, pellet, wax block, liquid bait and concentrate formulations.
0.3
Low
22900
Acetone
-
16800
Ethanol
-
1224
Heptane
-
43000
Xylene
-
146
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
7.08 X 1004
Calculated
-
4.85
High
-
-
-
-
-
-
1.28
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Not applicable
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Acidic
1.37 X 10-05
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Low volatility
1.55 X 10-05
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Non-volatile
-
-
-
-
-
-
-
5
S1 S = Expert judgement 1 = Estimated data with little or no verification
Non-persistent
-
-
-
102
Persistent
-
-
-
-
-
-
-
-
-
Best available data - literature variable DT₅₀ 1-150 days
-
-
-
-
-
-
-
-
-
-
-
-
Stable
Stable
-
-
-
-
-
-
-
Soil adsorption and mobility
-
S3 S = Expert judgement 3 = Unverified data of known source
Slightly mobile
2255
Other data source: 5477 mL g⁻¹ (US3)
-
-
-
-
-
-
-
1.30
Calculated
Low leachability
3.11 X 10-02
Calculated
-
-
Medium
Calculated
-
Slightly mobile
Calculated
-
-
-
-
-
-
None
Terrestrial ecotoxicology
2.3
Rat
High
-
L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source
Rat
-
0.1
-
-
-
-
> 3158
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Anas platyrhynchos
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2.8
Oncorhynchus mykiss
Moderate
-
-
-
1.8
Daphnia magna
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
2.3
Rat
High
200
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
2.0
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Highly toxic Anticoagulant
No information available
Health: H300, H372
Ia (Extremely hazardous)
2588
-
diphacinone
diphacinone
Diphacinon
diphacinon
difacinone
difacinone
diphacinone
difacynon
-
-
difacinon
Record last updated:
16/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242