The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Ecotoxicity High alert: Fish chronic ecotoxicity: High
Human health High alert: Carcinogen; Reproduction/development effects
GENERAL INFORMATION
Description
A prochloraz-metal complex active against a wide range of fungal diseases affecting fruit and many other crops
Example pests controlled
Collar-rot, Various moulds, Post-harvest decay; Black dot; Silver scurf, Powdery mildew
Example applications
Fruit including cherries, apricots, plums, peaches, avocados, banana, citrus, litchies; Mushrooms; Seed potatoes
Broad-spectrum with protectant and eradicant properties. Disrupts membrane function.
CAS RN
137001-93-5
EC number
No data found
CIPAC number
407
US EPA chemical code
-
PubChem CID
-
CLP index number
No data found
Molecular mass
-
Chemical name
Prochloraz-zinc complex
PIN (Preferred Identification Name)
-
IUPAC name
-
CAS name
-
Other status information
-
Relevant Environmental Water Quality Standards
UK non-statutory standard for the protection of aquatic life: freshwater and saltwater annual average: 4 ug prochloraz/L; max acceptable conc: 40 ug prochloraz/L
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
Dog SF=100 as prochloraz
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
0.025
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
Dog SF=100 as prochloraz
-
Dermal penetration studies (%)
1.2-3.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
concentration dependent
-
Dangerous Substances Directive 76/464
-
-
-
Exposure Routes
Public
No unacceptable risks to bystanders identified
Occupational
No unacceptable risks to operators or other workers identified
MRLs
European
EU MRL pesticide database
Great Britain
GB MRL Register
Notes
-
Drinking Water Standards
-
-
-
Drinking Water MAC (μg l⁻¹)
0.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
EU Dir 89/778/EC limit; Calc MAC=30 µg prochloraz/L
-
Mammalian dose elimination route and rate
-
-
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
✓Yes, known to cause a problem
A3 A = Chromosome aberration (EFSA database) 3 = Negative
;
B2 B = DNA damage/repair (EFSA database) 2 = Mixed/ambiguous results
;
C3 C = Gene mutation (EFSA database) 3 = Negative
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
?Possibly, status not identified
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Eye irritant
Phototoxicant
✓Yes, known to cause a problem
No data found
General human health issues
Possible liver toxicant USEPA - possible human carcinogen Endocrine issues - Activation of Pregnane X cellular receptor
Handling issues
Property
Value and interpretation
General
Not explosive or oxidising IMDG Transport Code is usually 9 Not expected to autoignite; Not highly flammable
CLP classification 2013
Health: H302 Environment: H400, H410
WHO Classification
II (Moderately hazardous)
UN Number
3082
Waste disposal & packaging
Contain/absorb spillage in suitable inert, absorbent material. Transfer to heavy duty plastic drums. Dispose in approved manner Packaging Group III (minor danger)
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Ecotoxicity
