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guazatine (Ref: EM 379)
** guanoctine ** MC 25 ** guazatine triacetate ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for guazatine

Description: A fungicide seed dressing used to control a range of pathogens mainly on citrus fruit.

Example pests controlled: Septoria, Fusarium and Helminthosporium spp.

Example applications: Citrus fruits including oranges, manderines, lemons, grapefruit, pineapple, melon; Sugarcane

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1974, Sweden

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C18H41N7
Canonical SMILES C(CCCCN=C(N)N)CCCNCCCCCCCCN=C(N)N
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RONFGUROBZGJKP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H41N7/c19-17(20)24-15-11-7-3-1-5-9-13-23-14-10-6-2-4-8-12-16-25-18(21)22/h23H,1-16H2,(H4,19,20,24)(H4,21,22,25)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Guanidine
Minimum active substance purity 500 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Inhibition of lipid biosynthesis. Multi-site activity. Broad-spectrum.
CAS RN 108173-90-6
EC number 236-855-3
CIPAC number 361
US EPA chemical code -
PubChem CID 3526
Molecular mass (g mol-1) 355.57
PIN (Preferred Identification Name) -
IUPAC name guazatine triacetate
CAS name 1,1'-(Iminobis(octamethylene))diguanidine
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) M7
Examples of recorded resistance -
Physical state Brown solid, product is orange liquid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Makhteshim-Agan
  • Murphy
  • Kenogard
Example products using this active
  • Ravine Plus
  • Panoctine 35
  • Kenopel
UK LERAP status None
Formulation and application details Often supplied as an aqueous solution for use as a seed treatment.


ENVIRONMENTAL FATE

for guazatine

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 6000000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 2000000 B4 - Ethanol -
510000 A4 - Methanol -
100 A5 - Acetone -
100 A5 - Toluene -
Melting point (oC) 60 A4 -
Boiling point (oC) 100 A3 -
Degradation point (oC) 165 A3 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.00 X 10-04 Calculated -
Log P -4.0 A3 Low
Bulk density (g ml-1)/Specific gravity 1.06 B5 -
Dissociation constant (pKa) at 25oC 10 A5 -
Note: Pka(2) = 4.6, Acetate salt of strong base
Vapour pressure at 20oC (mPa) 0.01 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.80 X 10-08 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.19 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 No absorbance above 290nm A5 -
Surface tension (mN m-1) 66.87 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 18 A5 Non-persistent
DT50 (lab at 20oC) 18 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 61 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 10.8-38.2 days, DT90 range 36-127 days; Other studies Lab studies DT50 range 400-600 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 469 R3 -
Note Apple leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 30 C4 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable C4 -
Note Stable pH 5 to pH 9 for 30 days at 25 degC
Water-sediment DT50 (days) 100 Q3 Slow
Water phase only DT50 (days) 30 Q3 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - Q3 Non-mobile
Koc 25000
Notes and range Literature Koc range 3646-46250 mL/g
Freundlich Kf 492.1 A5 Non-mobile
Kfoc 14152
1/n 1.09
Notes and range EU dossier Kf range 85.33-2404 mL/g, Kfoc range 3646-15390 mL/g, 1/n range 0.999=1.271, Soils=7
pH sensitivity No


ECOTOXICOLOGY

for guazatine

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 0.04 Q3 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 308 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) > 10 B5 Rat High
(ppm diet) > 200 -
Birds - Acute LD50 (mg kg-1) 57.9 A3 Columba livia High
Birds - Short term dietary (LC50/LD50) 164.4 mg kg bw-1 day-1 A4 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.42 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.044 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.15 B3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0135 C4 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 59 B5 Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 3420 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 14.4 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for guazatine

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 308 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 1064 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.163 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0048 A5 Dog, SF=500 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.04 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.002 A5 Dog, SF=100 -
Dermal penetration studies (%) 0.4-6.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Moderately toxic
Although no conclusive evidence regarding carcinogenity available some sutudies raise concerns

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
Ensure adequate ventilation when using
IMDG Transport Code is usually 9
CLP classification 2013 Health: H302, H312, H315, H318, H330, H335
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20/22, R41
Xi - Irritant: R37/38
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for guazatine

Language Name
English guazatine
French triacétate de guazatine
German Guazatin
Danish guazatin
Italian guazatina
Spanish guazatina
Greek -
Slovenian guazatin
Polish guazatyna
Swedish guazatinacetater
Hungarian guazatin
Dutch -

Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk