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quizalofop-P-ethyl (Ref: DPX 79376)
** quizalofop-P ** NC-302-acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for quizalofop-P-ethyl

Description: An post-emergence annual and perennial grass weed herbicide in sugerbeetand other crops

Example pests controlled: Bentgrass; Volunteer cereals; Perennial ryegrass; Italian ryegrass; Couch

Example applications: Sugarbeet; Fodder beet; Winter and spring OSR; Potatoes; Combining peas; Field beans; Other pulses; Linseed; Sunflowers

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1989

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Finland/UK
Date inclusion expires 30/11/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule. Quizalofop-P-ethyl is the more biologically active enantimer of the racemate quizalofop-ethyl.
Chemical formula C19H17ClN2O4
Canonical SMILES CCOC(=O)C(C)OC1=CC=C(C=C1)OC2=CN=C3C=C(C=CC3=N2)Cl
Isomeric SMILES CCOC(=O)[C@@H](C)OC1=CC=C(C=C1)OC2=CN=C3C=C(C=CC3=N2)Cl
International Chemical Identifier key (InChIKey) OSUHJPCHFDQAIT-GFCCVEGCSA-N
International Chemical Identifier (InChI) InChI=1S/C19H17ClN2O4/c1-3-24-19(23)12(2)25-14-5-7-15(8-6-14)26-18-11-21-17-10-13(20)4-9-16(17)22-18/h4-12H,3H2,1-2H3/t12-/m1/s1
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Aryloxyphenoxypropionate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Selective. An acetyl CoA carboxylase inhibitor (ACCase).
CAS RN 100646-51-3
EC number -
CIPAC number 641.202
US EPA chemical code -
PubChem CID 1617113
Molecular mass (g mol-1) 372.81
PIN (Preferred Identification Name) ethyl (2R)-2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoate
IUPAC name ethyl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionate
CAS name ethyl (2R)-2-(4-((6-chloro-2-quinoxalinyl)oxy)phenoxy)propanoate
Other status information Severe Marine Pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) A
Herbicide Resistance Classification (WSSA) 1
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Bromus rigidus
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Makhteshim
  • Nissan
  • FCC
  • Kingtai Chemicals
Example products using this active
  • Leopard EC
  • Pilot Ultra
  • Targa Super
  • Matador
UK LERAP status None
Formulation and application details Often supplied as emulsifiable or soluble concentrates that are mixed with water and used as a spray.


ENVIRONMENTAL FATE

for quizalofop-P-ethyl

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.61 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 250000 A5 - Acetone -
250000 A5 - Ethyl acetate -
250000 A5 - Xylene -
34870 A5 - Methanol -
Melting point (oC) 75.0 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 320 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 4.07 X 1004 Calculated -
Log P 4.61 A5 High
Bulk density (g ml-1)/Specific gravity 1.36 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.10 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 6.70 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.29 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.35 X 10-05 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution 343nm = 6342; [Acidic solution 343nm = 6356; [Basic solution 343nm = 6242 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 2 K4 Non-persistent
DT50 (lab at 20oC) 0.4 A5 Non-persistent
DT50 (field) 1.8 A5 Non-persistent
DT90 (lab at 20oC) 1.9 A5 -
DT90 (field) 5.7 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 0.1-1.1 days, DT90 range 1.1-3.5 days; field studies DT50 range 0.55-8.2 days, DT90 range 1.8-27.4 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.6 R3 -
Note OSR straw, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 38.3 A5 Stable
Note Data for continuous light, DT50 40.2 days in natural light 40 deg N
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 112 A5 Persistent
Note pH and temperature sensitive: Stable at pH 4 and 50 degC, DT50 10.7 days at pH 7 and 40 degC, 4 days at pH 7 and 50 degC, unstable at pH 9 and 50 degC
Water-sediment DT50 (days) 1.51 A5 Fast
Water phase only DT50 (days) 1.55 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 49.9 A5 Slightly mobile
Kfoc 1816
1/n 0.86
Notes and range EU dossier Kf range 15.4-99.3, Kfoc range 1024-3078 mL/g, 1/n range 0.83-0.88, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
quizalofop (Ref: CGA 287422) This metabolite may cause environmental pollution, click here for further information Soil   0.838   Major fraction, Relevant
hydroxy quizalofop (Ref: CGA 294972) This metabolite may cause environmental pollution, click here for further information Soil   0.157   Major fraction, Relevant
dihydroxy quinoxaline (Ref: CGA 294970) This metabolite may cause environmental pollution, click here for further information Soil   0.123   Major fraction, Relevant


ECOTOXICOLOGY

for quizalofop-P-ethyl

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 380 A5 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 1182 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 7.7 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.21 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.044 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.29 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.023 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.098 A5 Lemna gibba Moderate
Non-target plants 52.31 A5 Zea mays
Seedling emergence, ER50
as g/ha
-
5.46 A5 Zea mays
Vegetative vigour, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.021 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 1 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 25 Mortality
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 48.5 Mortality
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 925 g ha-1, 60 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for quizalofop-P-ethyl

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1182 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat (racemate) -
Mammals - Inhalation LC50 (mg l-1) 5.8 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0013 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.01 A5 Mouse, SF=100 -
Dermal penetration studies (%) 18-28 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk to bystanders
Occupational Operators require PPE
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
Combustiable
IMDG Transport Code is usually 3
CLP classification 2013 Health: H304, H319, H336
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) - -
UN Number Usually 1993
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for quizalofop-P-ethyl

Language Name
English quizalofop-P-ethyl
French quizalofop-P-ethyl
German Quizalofop-P-ethyl
Danish quizalofop-P-ethyl
Italian quizalofop-etile-isomero D
Spanish quizalofop-P-etil
Greek -
Slovenian kvizalofop-P-etil
Polish kwizalofop-P-etylowy
Swedish -
Hungarian quinzalofop-P-etil
Dutch -

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk