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GET ADDITIONAL DATA HERE!

thiamethoxam (Ref: CGA 293343)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for thiamethoxam

Description: A insecticide used to control a wide range of common pests

Example pests controlled: Aphids; Whiteflies; Thrips; Lacewings; Leafhoppers; Mealybugs; Wireworms; Ground beetles; Fire & carpenter ants; Craneflies; Mole crickets

Example applications: Turf grass & sod farms; Landscape plants; Ornamentals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1991, discovered; 1997, first registered New Zealand

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France/Spain
Date inclusion expires 30/04/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric - exists in both the E- and Z- forms. Technical product is a mixture.
Chemical formula C8H10ClN5O3S
Canonical SMILES CN1COCN(C1=N[N+](=O)[O-])CC2=CN=C(S2)Cl
Isomeric SMILES CN\1COCN(/C1=N/[N+](=O)[O-])CC2=CN=C(S2)Cl
International Chemical Identifier key (InChIKey) NWWZPOKUUAIXIW-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8+
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Neonicotinoid
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Broad spectrum, systemic with contact and stomach action. Acetylcholine receptor (nAChR) agonist.
CAS RN 153719-23-4
EC number 428-650-4
CIPAC number 637
US EPA chemical code 060109
PubChem CID 5821911
Molecular mass (g mol-1) 291.71
PIN (Preferred Identification Name) (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
IUPAC name (EZ)-3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene(nitro)amine
CAS name 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine
Other status information NOTE ban or usage restriction may be in place for use on flowering crops in some Member States
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 4A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Bemisia tabaci
Leptinotarsa decemlineata
Myzus persicae
Physical state Crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
  • AgroCare
  • Kingtai Chemicals
Example products using this active
  • Actara
  • Cruiser SB
  • Centric
  • Flagship
  • Meridian
  • Optigard
  • Platinum
UK LERAP status None (may vary with mixtures)
Formulation and application details Formulations include flowable concentrates for seed treatments, water dispersible granules and suspension concentrates.


ENVIRONMENTAL FATE

for thiamethoxam

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 4100 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 48000 A5 - Acetone -
7000 A5 - Ethyl acetate -
1 A5 - Hexane -
680 A5 - Toluene -
Melting point (oC) 139.1 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 147 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.41 X 10-01 Calculated -
Log P -0.13 A5 Low
Bulk density (g ml-1)/Specific gravity 1.57 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 6.60 X 10-06 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.70 X 10-10 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.69 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.14 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 255nm = 16800, No absorption maximum between 290nm and 750nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 50 L3 Moderately persistent
DT50 (lab at 20oC) 121 A5 Persistent
DT50 (field) 39 A5 Moderately persistent
DT90 (lab at 20oC) 459 A5 -
DT90 (field) 296.5 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 34-233 days, DT90 range 114-907 days; field studies DT50 range 7-72 days, DT90 range 23-570 days; Other sources: DT50 range 34-53 days (DW3)
Dissipation rate RL50 on plant matrix Value 3.2 R3 -
Note Tomato leaves, n=1
Dissipation rate RL50 on and in plant matrix Value 4.4 R4 -
Note Published literature RL50 range 1.3-9.1 days, 8 field grown crops, various matrices, n=11
Aqueous photolysis DT50 (days) at pH 7 Value 2.7 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: stable pH 1 to pH 7, DT50 11.5 days at pH 9, all at 20 degC
Water-sediment DT50 (days) 40 A5 Moderately fast
Water phase only DT50 (days) 30.6 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - A5 Mobile
Koc 56.2
Notes and range Other sources: Koc = 245 mL/g (DW3); General literature 70 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
clothianidin (Ref: CGA 322704) This metabolite may cause environmental pollution, click here for further information Soil   0.356   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: CGA 355190) - Soil (Aerobic) 0.231 -
(Ref: NOA 407475) - Soil (Anaerobic) 0.634 -
(Ref: NOA 459602)
Note: Potential groundwater pollutant
- Soil - -
(Ref: SYN 501406)
Note: Potential groundwater pollutant
- Soil - -


ECOTOXICOLOGY

for thiamethoxam

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 1563 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 576 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) > 2503 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 125 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 20 A4 Oncorhynchus mykiss, 88 days Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 L3 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) > 100 E4 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.01 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 0.10 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 90 F3 Lemna gibba, 7 day Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 100 L3 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.024 A5 High
Oral acute 48 hour LD50 (μg bee-1) 0.005 A5 High
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 5.34 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.2 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.2 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 10 x field rate
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for thiamethoxam

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 1563 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 3.72 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.026 A5 Mouse, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.5 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.08 A5 Dog, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Increased incidence of liver cell adenoma and adenocarcinoma in Mouse

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
CLP classification 2013 Health: H302
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for thiamethoxam

Language Name
English thiamethoxam
French thiamethoxam
German Thiamethoxam
Danish thiamethoxam
Italian tiametoxam
Spanish tiametoxam
Greek -
Slovenian tiametoksam
Polish tiametoksam
Swedish tiametoxam
Hungarian tiametoxam
Dutch thiamethoxam

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk