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DDD (Ref: ENT 4225)
** dichlorodiphenyldichloroethane ** tetrachlorodiphenylethane ** TDE ** p,p'-DDD ** ME-1700 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

DDD is a banned and obsolete insecticide that is also a metabolite of DDT. It is practically insoluble in water and is not highly volatile. It is, like DDT, very environmentally perssitent in both soils and water. It is toxic to humans through ingestion, inhalation and via skin absorption and has been linked with cancer, is mutagenic and various negative reproduction/fertility effects. It is also an endocrine disrupter. It is toxic to most animal species but data is not abundant.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for DDD

Description: A now obsolete insecticide that was formerly used to kill a wide range of insect pests especially those that carry disease. It is also a pesticide transformation product of DDT

Example pests controlled: Mosquitoes; Lice

Example applications: Vegetables; Cotton; Peanuts; Forestry; Public health situations

Efficacy & activity: Not applicable

Availability status: Obsolete, banned

Introduction & key dates: 1944, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Consists of three isomeric forms p,p'-DDD, o,p'-DDD and o,o'-DDD. p,p'-DDD is the dominant isomer.
Chemical formula C14H10Cl4
Canonical SMILES C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) AHJKRLASYNVKDZ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H10Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8,13-14H
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Metabolite
Metabolite Type Soil
Substance group Organochlorine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Non-systemic stomach and contact action
CAS RN 72-54-8
EC number 200-783-0
CIPAC number 199
US EPA chemical code 029101
PubChem CID 6294
Molecular mass (g mol-1) 320.04
PIN (Preferred Identification Name) -
IUPAC name 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane
CAS name 1,1'-(2,2-dichloroethylidene)bis(4-chlorobenzene)
Other status information Common environmental pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 2A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Clear to off-white coloured crystals
Related substances & organisms -

Can be a metabolite of:
Parent Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
DDT Soil     Not assessed under 91/414 or 1107/2009
p,p'-DDT Soil   Null   Not assessed under 91/414 or 1107/2009
o,p'-DDT Soil   Null   Not assessed under 91/414 or 1107/2009
o,o'-DDT Soil   Null   Not assessed under 91/414 or 1107/2009

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Rohm & Haas
Example products using this active
  • Rhothane
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

for DDD

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.09 F4 Low
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 110 F4 -
Boiling point (oC) 350 F4 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable V3 -
Octanol-water partition coefficient at pH 7, 20oC P 1.05 X 1006 Calculated -
Log P 6.02 F4 High
Bulk density (g ml-1)/Specific gravity 1.385 F4 -
Dissociation constant (pKa) at 25oC Not applicable R3 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.18 V3 - @ 25 degC Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.0 X 10-06 F4 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -2.46 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not considered to be biodegradeable.
Soil degradation (days) (aerobic) DT50 (typical) 1000 F3 Very persistent
DT50 (lab at 20oC) 160 Q3 Persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Environmentally stable
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable Q3 -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - V3 Non-mobile
Koc 131000
Notes and range Literature data ranges 130600 to 131800 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for DDD

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 113 V3 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 4814 F4 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 0.07 F4 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 0.009 F4 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for DDD

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 113 V3 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 1200 V3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints > 10000 V3 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I - -
Exposure Limits - - -
Exposure Routes Public Risk from residues in food but the substance is now banned
Occupational PPE/PPC essential
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards US drinking water standards are variable by State: Minnesota 1.0 ug/L, Florida 0.1 ug/L F4 -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Moderately toxic by ingestion, inhalation and skin absorption
Endocrine issues - Competitive binding to androgen receptors
Whilst DDD is linked with cancer one particular isomeric form (o,p'-DDD) has been used to treat cancer of the adrenal gland

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Combustible
Incompatible with alkalis, strong oxidisers
CLP classification 2013 Health: H301, H312, H351
Environment: H400, H401
EC Risk Classification Click here to view information omn the EU risk phrases Not classified: Obsolete
EC Safety Classification Click here to view information omn the EU safety phrases Not classified: Obsolete
WHO Classification O - Obsolete substance
US EPA Classification (formulation) - -
UN Number 2761
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for DDD

Language Name
English DDD
French TDE
German TDE
Danish TDE
Italian TDE
Spanish TDE
Greek -
Slovenian diklorodifenildikloroetan
Polish dichlorodifenylodichloroetan
Swedish -
Hungarian -
Dutch TDE

Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk