Nicarbazin |
Last updated: 10/01/2024 |
(Also known as: nicarbazine) |
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A carbanilide type medicinal feed additive | |
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2005, introduced | |
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Used to treat a protozoan disease - coccidiosis in chickens and for egg hatch reduction in Canada Geese | |
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Domestic fowl; Canada geese |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₉H₁₈N₆O₆ | |
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CC1=CC(=NC(=O)N1)C.C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-] | |
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No data | |
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UKHWDRMMMYWSFL-UHFFFAOYSA-N | |
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InChI=1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9) | |
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Yes |
General status |
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Coccidiostat, Antiprotozoal agent, Feed additive | |
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Carbanilide drug | |
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Synthetic | |
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Inhibits the formation of the vitelline membrane separating the egg yolk and egg white | |
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[Succinate, Inhibitor], [Energy-dependent transhydrogenases, Inhibitor] | |
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330-95-0 | |
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206-359-1 | |
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85712 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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QP51AE03 | |
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No | |
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426.38 | |
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A complex of two compounds, 4,4'-dinitrocarbanilide (DNC) and 4,6-dimethyl-2-pyrimidinol (HDP) | |
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N,N'-bis(4-nitrophenyl)-urea (DNC), compound with 4,6-dimethyl-2(1H)-pyrimidinone (1:1) (HDP) | |
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Not approved as a feed additive in EU | |
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Yellow to tan coloured powdery solid | |
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Formulations |
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Maxiban G160 | Elanco Animal Health | Not licensed | Not licensed | ||||||
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0.52 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low | ||||||||
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270 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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5.75 X 1003 | Calculated | - | |||||||
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3.76 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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0.5 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Produces a band of absorption in the range of 300-360mm | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Degradation |
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301 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Persistent | |||||||
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The DNC portion degrades slowly in soil with DT₅₀ ~ 1yr & does not volatilize or leach through the soil. DNC and HDP will have different fate profiles | ||||||||||
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>8 | R4 R = Peer reviewed scientific publications Broiler faeces Slightly persistent4 = Verified data |
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602 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Stable | |||||||
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Stable | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Stable | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 3680 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anas platyrhynchos4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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> 0.069 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss for DNC fraction4 = Verified data |
High | ||||||||
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> 0.093 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna for DNC fraction4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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5000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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> 0.147 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Metabolised and excreted mainly in the faeces | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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No further information available |
Handling issues |
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Not expected to auto-ignite; Not highly flammable | |||
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Not listed (Not listed) | |||
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nicarbazin | ||
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Record last updated: | 10/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |