Narasin |
Last updated: 08/02/2024 |
(Also known as: (4S)-4-methyl-salinomycin; compound 79891; antibiotic A 28086A ) |
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A veterinary ionophone coccidiostat and antibacterial agent | |
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Mainly used to prevention of coccidiosis, as a performance and growth enhancer | |
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Chickens; Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₄₃H₇₂O₁₁ | |
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CCC(C1C(CC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C)C(=O)O | |
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CC[C@H]([C@H]1[C@H](C[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C)C(=O)O | |
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VHKXXVVRRDYCIK-CWCPJSEDSA-N | |
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InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1 | |
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Yes |
General status |
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Coccidiostat, Antiobiotic, Antibacterial, Antiparasitic, Growth stimulant, Feed additive | |
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Ionophore | |
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Synthetic | |
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Dissociates the calcium fluxes in muscle fibers | |
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55134-13-9 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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QP51AH04 | |
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No | |
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765.03 | |
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(2R)-2-[(2R,3S,5S,6R)-6-[(1S,2S,3S,5R)-5- [(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-2-tetrahydropyranyl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]-3,5-dimethyl-2-tetrahydropyranyl]butanoic acid | |
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White to off-white, crystalline powder | |
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Formulations |
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Maxiban G160 | Elanco Animal Health E772 | Not licensed | Not licensed | ||||||
Monteban | Elanco Animal Health E772 | Not licensed | Not licensed | |||||||
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102 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Moderate | ||||||||
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98 | L3 L = Pesticide manuals and hard copy reference books / other sources resolidifies remelts at 1983 = Unverified data of known source |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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217 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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7.08 X 1004 | Calculated | - | |||||||
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4.85 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
High | ||||||||
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7.9 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Ethanol: 285nm | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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8.8 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | |||||||
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35 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Moderately persistent | ||||||||
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116 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Persistent | ||||||||
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USEPA data: DT₅₀ range 21-49 days, DT₉₀ 69-162 days | ||||||||||
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1.5 | F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source |
Moderately fast | |||||||
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Susceptible to photolysis | ||||||||||
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Stable | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Stable | |||||||
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Stable pH 7 and 9, DT₅₀ 3.5 days at pH 5 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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88 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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1619 | ||||||||||
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USEPA data Kd range 7.1 to 108 mL g⁻¹, Koc range 507-3670 mL g⁻¹, Soils=5 | ||||||||||
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Fate indices |
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1.22 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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dihydroxynarasin | - | Animal (Liver) | - | ||||
9-keto-trihydroxynarasin | - | Animal (Liver) | - | ||||
hydroxynarasin | - | Animal (Liver) | - | ||||
trihydroxynarasin | - | Animal (Liver) | - |
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Terrestrial ecotoxicology |
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21.2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
High | ||||||||
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75.57 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
High | ||||||||
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> 20 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris3 = Unverified data of known source |
Moderate | ||||||||
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0.5 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 3.27 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lepomis macrochirus4 = Verified data |
Moderate | ||||||||
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0.033 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lepomis macrochirus4 = Verified data |
Moderate | ||||||||
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> 7.72 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.077 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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21.2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
High | ||||||||
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Intravenous LD₅₀ = 1.96 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 7.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Rapidly metabolised in liver and eliminated in faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause behavioural and gastrointestinal problems |
Handling issues |
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IMDG Transport Hazard Class 9 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group II (moderate danger) | |||
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narasin | ||
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narasine | ||
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narasino | ||
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Record last updated: | 08/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |