Dexamethasone isonicotinate |
Last updated: 09/02/2024 |
(Also known as: dexamethasone-21-isonicotinate) |
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An anti-inflammatory corticosteroid veterinary drug | |
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Current | |
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Used, for example, for the control of CNS inflammation in dogs and cats and for the treatment of primary bovine ketosis. | |
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Cattle; Horses; Lamas; Elephants; Pigs; Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₈H₃₂FNO₆ | |
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CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C | |
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C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C | |
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BQTXJHAJMDGOFI-NJLPOHDGSA-N | |
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InChI=1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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dexamethasone | Parent |
General status |
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Anti-inflammatory | |
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Corticosteroid | |
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Synthetic | |
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Unbound dexamethasone crosses cell membranes and binds to specific cytoplasmic receptors leading to a reduction in inflammation | |
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[Glucocorticoid receptor, Agonist], [Nuclear receptor 0B1, stimulator], [Annexin A1, stimulator], [Nitric oxide synthase, inducible, Negative modulator] | |
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2265-64-7 | |
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68402-70-0 | |
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218-866-5 | |
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16752 | |
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Alimentary tract & metabolism; Cardiovascular system; Dematologicals; Systemic hormone preparations excluding sex hormones & insulins; Respiratory system; Sensory organs | |
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QA01AC02; QC05AA09; QD07AB19; QH02AB02; QR01AD03; QS01BA01; QS02BA06; QS03BA01 | |
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Allowed substance (Table 1 Bovine, Caprine, Porcine, Equidae) | |
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497.6 | |
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[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] pyridine-4-carboxylate | |
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Formulations |
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Trovex Suspension for Injection | Emdoka bvba | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Available in a variety of formulations including solutions for injection, chewable tables and dropper suspension solutions as ear drops |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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Metablised and around 30% excreted in the urine within 4 days. Also excreted in human breast milk. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause hypertension May cause retinal toxicity, glaucoma & subcapsular cataract May cause delayed wound healing, atrophy & skin fragility |
Handling issues |
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Emits toxic fumes of hydrogen fluoride when heated to decomposition | |||
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Not listed (Not listed) | |||
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dexamethasone isonicotinate | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |