| paraquat dichloride |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for paraquat dichloride
Description: A herbicide used to control common weeds and grasses in a wide range of agricultural and amenity situations
Example pests controlled: Broad-leaved weeds including cocksfoot; Grasses including wild oats, Yorkshire fog grass, ryegrass, fescue
Example applications: Rice; Lucerne; Beans & peas; Hops; Vineyards; Potaoes; Non-cropped areas such as roadways, paths
Efficacy & activity: -
Availability status: Unknown
Introduction & key dates: -
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | UK |
| Date inclusion expires | Not applicable |
| EU Candidate for substitution (CfS) | - |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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General status:
| Pesticide type | Herbicide | |||
| Substance group | Quarternary ammonium compound | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | EU dossier - free 4,4¢-bipyridyl 0.2% | |||
| Substance origin | Synthetic | |||
| Mode of action | Broad-spectrum, non-residual activity with contact and some desiccant action. Photosystem I (electron transport) inhibitor. | |||
| CAS RN | 1910-42-5 | |||
| EC number | 217-615-7 | |||
| CIPAC number | - | |||
| US EPA chemical code | 061601 | |||
| Isomerism | - | |||
| Chemical formula | C12H14Cl2N2 | |||
| SMILES | c1(c2cc[n+](C)cc2)cc[n+](C)cc1.[ClH-].[ClH-] | |||
| International Chemical Identifier key (InChIKey) | FIKAKWIAUPDISJ-UHFFFAOYSA-L | |||
| International Chemical Identifier (InChI) | InChI=1S/C12H14N2.2ClH/c1-13-7-3-11(4-8-13)12-5-9-14(2)10-6-12;;/h3-10H,1-2H3;2*1H/q+2;;/p-2 | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 257.16 | |||
| PIN (Preferred Identification Name) | 1,1'-dimethyl-[4,4'-bipyridine]-1,1'-diium dichloride | |||
| IUPAC name | 1,1'-dimethyl-4,4'-bipyridinium dichloride | |||
| CAS name | 1,1'-dimethyl-4,4'-bipyridinium dichloride | |||
| Other status information | PAN Dirty Dozen; Chemical subject to PIC regulations | |||
| Herbicide Resistance Classification (HRAC) | D | |||
| Herbicide Resistance Classification (WSSA) | 22 | |||
| Insecticide Resistance Classification (IRAC) | Not applicable | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | Lolium rigidum | |||
| Physical state | off-white crystalline solid | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use or outside scope | |||
| Formulation and application details | Usually formulated as a soluble concentrate or aqueous liquid. | |||
ENVIRONMENTAL FATE
for paraquat dichloride
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 620000 | E4 | High | |
| Solubility - In organic solvents at 20oC (mg l-1) | 100 | A4 - Acetone | - | |
| 100 | A4 - Toluene | - | ||
| 100 | A4 - Ethyl acetate | - | ||
| 100 | A4 - Hexane | - | ||
| Melting point (oC) | Decomoses before melting | A5 - | - | |
| Boiling point (oC) | Decomposes before boiling | A5 | - | |
| Degradation point (oC) | 340 | A5 | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | A5 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 3.16 X 10-05 | Calculated | - |
| Log P | -4.5 | E4 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.5 | E4 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | E4 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 25oC (mPa) | 0.01 | E4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 4.0 X 10-09 | E4 | Non-volatile | |
GUS leaching potential index  |
-3.48 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 5.35 X 10-03 | Calculated | - |
| Note | Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW | |||
| Potential for particle bound transport index |
- | Calculated | High | |
| Maximum UV-vis absorption L mol-1 cm-1 | 290nm | A5 | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 365 | E4 | Very persistent |
| DT50 (lab at 20oC) | 365 | E4 | Very persistent | |
| DT50 (field) | 365 | E4 | Very persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | Stable and persistent, General literature DT50 up to 20 years | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | - | - | - |
| Note | - | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | Stable | E4 | - |
| Note | Stable at all relevant wavelengths | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | Stable | E4 | - |
| Note | Stable at all relevant pHs | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | A5 | Non-mobile |
| Koc | 100000 | |||
| Notes and range | EU dossier Koc range 8400-40000000 mL/g | |||
| Freundlich | Kf | 3240 | R4 | Non-mobile |
| Kfoc | 228537 | |||
| 1/n | 2.9 | |||
| Notes and range | Kf range 717-6260 mL/g; Kfoc range 14340-581000 mL/g; 1/n range 1.96-4.0, Soils=9 | |||
| pH sensitivity | None, adsorption correlates to soil clay content | |||
ECOTOXICOLOGY
for paraquat dichloride
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | Low risk | A5 Based on LogP < 3 | Low potential |
| CT50 (days) | - | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 110 | G4 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | 35 | A4 Unknown species | High | |
| Birds - Short term dietary (LC50/LD50) | 698 mg kg feed-1 | A4 Unknown species | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 15 | E4 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | 2.5 | F3 Oncorhynchus mykiss, 30day | Moderate | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 1.2 | E4 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | 0.01 | F4 Daphnia magna | Moderate | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | 0.367 | A5 Chironomus riparius | Moderate | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | > 100 | A5 Chironomus riparius | Low | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | 0.088 | E4 Lemna gibba | Moderate | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.32 | E4 Raphidocelis subcapitata | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | 72 | F4 | Moderate |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | > 48 | E3 | Moderate | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | > 1000 | A4 Eisenia foetida | Low | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | > 1000 | A4 Eisenia foetida, 7 day | Low | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 Dose: 720 kg ha-1, 1 year |
- | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for paraquat dichloride
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 110 | G4 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | - | - | - | |
| Mammals - Inhalation LC50 (mg l-1) | - | - | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.004 | A4 Dog, SF=100 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 0.005 | A4 Dog, SF=100 | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | 0.0004 | A4 Dog, SF=100 | - | |
| Dermal penetration studies (%) | 0.5 | A5 | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | [LT TWA 8hr: 0.1 mg/m3] | Occupation Exposure | - | |
| Exposure Routes | Public | No unacceptable risks to bystanders identified | ||
| Occupational | No unacceptable risks to operators or other workers identified | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Potential liver, kidney, stomach, intestine and respiratory system toxicant May damage lungs if inhaled |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Not explosive or oxidising IMDG Transport Code is usually 6.1 |
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| CLP classification 2013 | - | |||
| EC Risk Classification |
T+ - Very toxic: R26 T - Toxic: R24/25, R48/25 Xi - Irritant: R36/37/38 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S22, S28, S36/37/39, S45, S60, S61 | |||
| WHO Classification | II | - | Moderately hazardous | |
| US EPA Classification (formulation) | No consensus across products or no products available | - | - | |
| UN Number | Usually 2811 | |||
| Waste disposal & packaging |
Packaging Group I / II (great / medium danger) | |||
TRANSLATIONS
for paraquat dichloride
| Language | Name |
| English | paraquat dichloride |
| French | - |
| German | - |
| Danish | - |
| Italian | - |
| Spanish | - |
| Greek | - |
| Slovenian | - |
| Polish | - |
| Swedish | - |
| Hungarian | - |
| Dutch | - |
Record last updated: Friday 04 August 2017
Contact: aeru@herts.ac.uk