| aldicarb (Ref: ENT 27093) |
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SUMMARY
Aldicarb is an insecticide that is not approved for use in the EU. It is highly soluble and volatile. It is not persistent in soil but may be in in aqueous sustems. It is highly toxic to humans but has a low potential to bioaccumulate. It is a known endocrine disrupter, a neurotoxin and an inhibitor of acetyl cholinesterase. Aldicarb is highly toxic to birds and honeybees, and moderately toxic to most aquatic organisms and earthworms. GENERAL INFORMATION 
for aldicarb
Description: A soil applied, insecticide and nematicide used to control chewing, sucking and soil dwelling insects
Example pests controlled: Mites; Nematodes; Aphids
Example applications: Cucumbers; Water melons; Cotton; Peanut; Soybean; Potatoes
Efficacy & activity: -
Availability status: Current
Introduction & key dates: 1970, USA
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | UK |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia, USA
General status:
| Pesticide type | Insecticide, Acaricide, Nematicide | |||
| Substance group | Carbamate | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Systemic with contact and stomach action absorbed through roots. Acetylcholinesterase (AChE) inhibitor. | |||
| CAS RN | 116-06-3 | |||
| EC number | 204-123-2 | |||
| CIPAC number | 215 | |||
| US EPA chemical code | 098301 | |||
| Isomerism | Isomeric - a structural isomer of butocarboxime | |||
| Chemical formula | C7H14N2O2S | |||
| SMILES | O=C(O\N=C\C(SC)(C)C)NC | |||
| International Chemical Identifier key (InChIKey) | QGLZXHRNAYXIBU-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C7H14N2O2S/c1-7(2,12-4)5-9-11-6(10)8-3/h5H,1-4H3,(H,8,10)/b9-5+ | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 190.26 | |||
| PIN (Preferred Identification Name) | (5E)-7,7-dimethyl-4-oxa-8-thia-2,5-diazanon-5-en-3-one | |||
| IUPAC name | (EZ)-2-methyl-2-(methylthio)propionaldehyde O-methylcarbamoyloxime | |||
| CAS name | 2-methyl-2-(methylthio)propanal O-[(methylamino)carbonyl]oxime | |||
| Other status information | PAN Dirty Dozen; Potential groundwater contaminant; Marine Pollutant | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 1A | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | Leptinotarsa decemlineata Liriomyza munda Tetranychus urticae |
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| Physical state | White crystals | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | None | |||
| Formulation and application details | Products are usually supplied as granular formulations. | |||
ENVIRONMENTAL FATE
for aldicarb
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 4930 | B5 | High | |
| Solubility - In organic solvents at 20oC (mg l-1) | 180000 | B4 - Benzene | - | |
| 110000 | B3 - Toluene | - | ||
| 470000 | B4 - Dichloromethane | - | ||
| 380000 | B4 - Acetone | - | ||
| Melting point (oC) | 99 | L3 | - | |
| Boiling point (oC) | Decomposes before boiling | V3 | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | V3 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 1.41 X 1001 | Calculated | - |
| Log P | 1.15 | B5 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.2 | L3 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | Q3 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 25oC (mPa) | 3.87 | B5 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.25 X 10-05 | H4 | Non-volatile | |
GUS leaching potential index  |
0.96 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 2.16 X 10-03 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Low | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 10 | Q3 | Non-persistent |
| DT50 (lab at 20oC) | 2.4 | B5 | Non-persistent | |
| DT50 (field) | 2 | R3 | Non-persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | Literature values DT50 range 1-60 days | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | 5.5 | R4 | - |
| Note | Published literature RL50 range 1.0-12.6 days, 7 field & undercover grown crops, various matrices, n=14 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | 8 | K4 | Moderately fast |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 189 | K4 | Persistent |
| Note | Hydrolysis is not greatly pH sensitive except in concentrated alkaline media | |||
| Water-sediment DT50 (days) | 6 | K3 | Fast | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | R3 | Mobile |
| Koc | 36 | |||
| Notes and range | General literature Koc 7.08-46.77 mL/g | |||
| Freundlich | Kf | 1.29 | G3 | Mobile |
| Kfoc | 30 | |||
| 1/n | 0.9 | |||
| Notes and range | Mean of 4 soils, 5 values. Sandy loam Kf=0.19; Loamy sand Kf=0.22; Loam Kf=2.47; Silt loam Kf=1.13 | |||
| pH sensitivity | - | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 1107/2009 relevancy |
|
| 2-methyl-2-(methylsulfinyl)propanal O-((methylamino)carbonyl)oxime |
Soil | 0.9 | Major fraction, Relevancy unknown | |
| aldoxycarb |
Soil | 0.2 | Major fraction, Relevancy unknown | |
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| aldicarb sulfone Note: DT50 soil = 48 days |
- | a = Soil; b = Plant; c = Rat (Urinary) | a=0.200 | - |
| aldicarb nitrile | - | Soil; Plant; Rat (Urinary) | - | - |
| aldicarb acid | - | Soil | - | - |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 42 | P4 | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 0.93 | F4 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | 3.4 | F3 Anas platyrhynchos | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.56 | L3 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | 1.37 | Q2 Unknown species | Moderate | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.42 | F4 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | 0.035 | L2 Daphnia magna | Moderate | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | 0.004 | F3 Chironomus riparius, 1 day | High | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 50 | F3 Skeletonema costatum | Low | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | > 0.28 | R4 | High |
| Oral acute 48 hour LD50 (μg bee-1) | > 0.16 | F3 | High | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | 65 | F4 Eisenia foetida | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for aldicarb
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 0.93 | F4 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 20 | L3 Rabbit | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.004 | L3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.003 | JMPR 1995 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 0.003 | JMPR 1995 | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | Consumer exposure to aldicarb and its toxic metabolites (the sulfoxide and sulfone) occurs mainly through food residues | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Highly toxic IARC Group 3 carcinogen, USEPA - possible human carcinogen at high doses Endocrine issues - Inhibition of 17 beta-estradiol and progesterone activity |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H330, H311, H300 Environment: H400, H410 |
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| EC Risk Classification |
T+ - Very toxic: R26/28 T - Toxic: R24 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S22, S36/37, S45, S61,S60 | |||
| WHO Classification | Ia | - | Extremely hazardous | |
| US EPA Classification (formulation) | I | - | Danger - Highly toxic | |
| UN Number | 2757 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | aldicarb |
| French | aldicarbe |
| German | Aldicarb |
| Danish | aldicarb |
| Italian | aldicarb |
| Spanish | aldicarb |
| Greek | - |
| Slovenian | aldikarb |
| Polish | aldikarb |
| Swedish | - |
| Hungarian | aldikarb |
| Dutch | aldicarb |
Record last updated: Tuesday 20 March 2018
Contact: aeru@herts.ac.uk