| aldrin (Ref: OMS 194) |
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SUMMARY
Aldrin is an obsolete organochlorine insecticide. It is banned from use in the EU and most of the developed world. It is virtually insoluble in water, quite volatile but unlikely to leach to groundwater. There are field studies that have shiown that aldrin can be persistent in soils. It is highly toxic to mammals and has a high potential for bioaccumulation. Aldrin is considered to be a carcinogen and neurotoxicant. It is highly toxic to most biodiversity. GENERAL INFORMATION 
for aldrin
Description: An obsolete persistent organochlorine insecticide that was mainly used to control soil dwelling insects
Example pests controlled: Termites; Wireworms; Rootworms; Weevils; Grasshoppers; White grubs; Corn root worm
Example applications: Corn; Alfalfa; Cotton; Vines; Bananas; Potted ornamentals
Efficacy & activity: -
Availability status: Obsolete, Banned
Introduction & key dates: circa 1950
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Not applicable |
| Date inclusion expires | Not applicable |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Chemical structure:
| Isomerism | A chiral molecule, aldrin is one of the several isomers of of hexachlorohexahydrodimethanonaphthalene. |
| Chemical formula | C12H8Cl6 |
| Canonical SMILES | C1C2C=CC1C3C2C4(C(=C(C3(C4(Cl)Cl)Cl)Cl)Cl)Cl |
| Isomeric SMILES | C1[C@@H]2C=C[C@H]1[C@H]3[C@@H]2[C@]4(C(=C([C@@]3(C4(Cl)Cl)Cl)Cl)Cl)Cl |
| International Chemical Identifier key (InChIKey) | QBYJBZPUGVGKQQ-SJJAEHHWSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C12H8Cl6/c13-8-9(14)11(16)7-5-2-1-4(3-5)6(7)10(8,15)12(11,17)18/h1-2,4-7H,3H2/t4-,5-,6-,7+,10-,11-/m0/s1 |
| 2D structure diagram/image available? | Yes |
Cambridge Crystallographic Data Centre diagrams:
| Common Name | Relationship | Link |
| Aldrin | Unstated isomer |  |
General status:
| Pesticide type | Insecticide | |
| Substance group | Organochlorine | |
| Minimum active substance purity | - | |
| Known relevant impurities | - | |
| Substance origin | Synthetic | |
| Mode of action | Central nervous system stimulant. GABA-gated chloride channel antagonist. Also stomach and contact toxin | |
| CAS RN | 309-00-2 | |
| EC number | 206-215-8 | |
| CIPAC number | 27 | |
| US EPA chemical code | 045101 | |
| PubChem CID | 12310947 | |
| Molecular mass (g mol-1) | 364.91 | |
| PIN (Preferred Identification Name) | (1R,4S,4aS,5S,8R,8aR)-1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8alpha-hexahydro-1,4:5,8-dimethanonaphthalene | |
| IUPAC name | (1R,4S,4aS,5S,8R,8aR)-1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8α-hexahydro-1,4:5,8-dimethanonaphthalene | |
| CAS name | (1R,4S,4aS,5S,8R,8aR)-rel-1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8α-hexahydro-1,4:5,8-dimethanonaphthalene | |
| Other status information | WFD priority substance; Subject to PIC regulations; POP - regulated by Stockholm Convention; PAN Dirty Dozen; LRTAP Annex I; OSPAR soc; Marine Pollutant; Rotterdam Convention (Class O) | |
| Relevant Environmental Water Quality Standards | EU Directive 2008/105/EC EQS sum of all cyclodiene pesticides in: inland surface waters: 0.01 ug/L; Other surface waters: 0.005 ug/L as annual average | |
| Herbicide Resistance Classification (HRAC) | Not applicable | |
| Herbicide Resistance Classification (WSSA) | Not applicable | |
| Insecticide Resistance Classification (IRAC) | 2A | |
| Fungicide Resistance Classification (FRAC) | Not applicable | |
| Examples of recorded resistance | Agriotes lineatus Agriotes obscurus Anopheles annularis Brontispa longissima Cylas formicarius plus others |
|
| Physical state | White to brown crystals | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | - | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 0.027 | F4 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 6000000 | A4 - Acetone | - | |
| 6000000 | A4 - Benzene | - | ||
| 6000000 | A4 - Xylene | - | ||
| Melting point (oC) | 104 | F4 | - | |
| Boiling point (oC) | 145 | V3 | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | V3 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 3.16 X 1006 | Calculated | - |
| Log P | 6.5 | F4 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.6 | F4 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | Q3 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 20oC (mPa) | 8.6 | F4 | Moderately volatile | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.72 X 1001 | V2 | Moderately volatile | |
GUS leaching potential index  |
-0.62 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 5.35 X 10-03 | Calculated | - |
| Note | Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 28 | G4 | Non-persistent |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | 365 | Q3 | Very persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | FAO state DT50 20-100 days | |||
| Dissipation rate RL50 on plant matrix | Value | 1.7 | R3 | - |
| Note | Alfalfa leaves, n=1 | |||
| Dissipation rate RL50 on and in plant matrix | Value | 7.0 | R3 | - |
| Note | Apples leaves, n=1 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | - | - | - |
| Note | - | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | H3 | Non-mobile |
| Koc | 17500 | |||
| Notes and range | Other sources: 500 mL/g (US3), 400-49000 mL/g (R3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 1107/2009 relevancy |
|
| dieldrin (Ref: ENT 16225 ) | Soil | - | Not assessed under 91/414 or 1107/2009 | |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 3348 | F3 (literature data ranges Log BCF 2.3-5.1 (R3)) | Threshold for concern |
| CT50 (days) | 1-5 | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 39 | F4 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | 6.6 | Q2 Colinus virginianus | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.0046 | J3 Lepomis macrochirus | High | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.028 | J4 Daphnia magna | High | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | - | - | - | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees (Apis spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | 0.35 | F2 | High | |
| Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Bumblebees (Bombus spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| - | ||||
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| - | ||||
| Mason bees (Osmia spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Other pollinators (1) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Other pollinators (2) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Earthworms - Acute 14 day LC50 (mg kg-1) | 60 | F2 | Moderate | |
| Earthworms - Chronic NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms | Acute LC50 (mg kg-1) | - | - | - | Chronic NOEC (mg kg-1) | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for aldrin
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 39 | F4 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | - | - | - | |
| Mammals - Inhalation LC50 (mg l-1) | - | - | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.0001 | A5 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 0.003 | A5 | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List I | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | May be absorbed through intact skin | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | 0.03 | PIC DGD - WHO recommendation max limit 0.03 μg l-1 | - | |
Health issues:
| Carcinogen | Genotoxic | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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A0; B0; C0; D0; E0 |
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Highly toxic by ingestion IARC group 3 carcinogen Endocrine issues - Competitive binding to androgen receptors |
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| Key: Genotoxicity A: Chromosome aberration (EFSA database) B: DNA damage/repair (EFSA database) C: Gene mutation (EFSA database) D: Genome mutation (EFSA database) E: Unspecified genotoxicity type (miscellaneous data source) 0: No data 1: Positive 2: Mixed/ambiguous results 3: Negative |
Key: Other : Yes, known to cause a problem  : No, known not to cause a problem  : Possibly, status not identified - : No data found |
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Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H301, H311, H351, H372 Environment: H400, H410 |
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| EC Risk Classification |
Carcinogen category 3: R40 T - Toxic: R24/25, R48/24/25 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S22, S45, S61, S36/37, S60 | |||
| WHO Classification | O | - | Obsolete substance | |
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | aldrin |
| French | aldrine |
| German | Aldrin |
| Danish | aldrin |
| Italian | aldrin |
| Spanish | aldrin |
| Greek | aldrin |
| Slovenian | aldrin |
| Polish | aldryna |
| Swedish | - |
| Hungarian | - |
| Dutch | aldrine |
Record last updated: Tuesday 30 October 2018
Contact: aeru@herts.ac.uk