Glyphosate-isopropylamine (Ref: MON 0139)

Glyphosate-isopropylamine (Ref: MON 0139)	Last updated: 02/03/2024
(Also known as: glyphosate-isopropyl ammonium; glyphosate; Isopropylamine glyphosate)

SUMMARY

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate Moderate alert: Potential for particle bound transport: Medium	Ecotoxicity Moderate alert: Birds chronic ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Earthworms chronic ecotoxicity: Moderate	Human health Moderate alert: Possible Carcinogen; Endocrine disrupter; Reproduction/development effects

GENERAL INFORMATION

Description

A herbicide used in a wide range of cropping, utility and industrial situations to control annual and perennial grasses and broad-leaved weeds

Example pests controlled

Annual and perennial weeds, Grasses

Example applications

Agriculture including cereals; Soybeans, Glyphosate tolerant crops; Horticulture; Forestry; Domestic gardens, lawns

Efficacy & activity

Efficacy demonstrated by field trials and extensive global use

Availability status

Current

Introduction & key dates

1971, first reported

UK regulatory status

UK COPR regulatory status

Approved

Date COPR inclusion expires

15/12/2025

UK LERAP status

Check label - may vary with formulation

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Assessment Group on Glyphosate

Date EC 1107/2009 inclusion expires

15/12/2033

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓	✓	✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓	✓	✓	✓	✓	✓	✓	✓	✓

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway
	✓

Additional information

Also used in

Australia, USA

Chemical structure

Isomerism

None

Chemical formula

C₆H₁₇N₂O₅P

Canonical SMILES

CC(C)N.C(C(=O)O)NCP(=O)(O)O

Isomeric SMILES

Not applicable

International Chemical Identifier key (InChIKey)

ZEKANFGSDXODPD-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C3H8NO5P.C3H9N/c5-3(6)1-4-2-10(7,8)9;1-3(2)4/h4H,1-2H2,(H,5,6)(H2,7,8,9);3H,4H2,1-2H3

2D structure diagram/image available?

Yes

Cambridge Crystallographic Data Centre diagrams

Common Name	Relationship	Link
glyphosate	Parent

General status

Pesticide type

Herbicide

Substance groups

Organophosphate herbicide; Phosphonoglycine herbicide

Minimum active substance purity

950 g kg⁻¹

Known relevant impurities

EU 2021 RAR: Formaldehyde <1g kg⁻¹; n-nitroso-glyphosate <1 mg kg⁻¹; Formic acid <4 g kg⁻¹; Triethylamine <2 g kg⁻¹

Substance origin

Synthetic

Mode of action

Broad-spectrum, systemic, contact action translocated and non-residual. Inhibition of EPSP synthase.

CAS RN

38641-94-0

EC number

254-056-8

CIPAC number

284.105

US EPA chemical code

103601

PubChem CID

38078

CLP index number

607-315-00-8

Molecular mass

228.18

PIN (Preferred Identification Name)

N-(phosphonomethyl)glycine isopropylammonium

IUPAC name

N-(phosphonomethyl)glycine isopropylammonium

CAS name

N-(phosphonomethyl)glycine isopropylammonium

Other status information

Risk of herbicide resistance developing - anti-resistance management required; PAN listed Highly Hazardous Chemical

Relevant Environmental Water Quality Standards

Herbicide Resistance Class (HRAC MoA class)

Herbicide Resistance Class (WSSA MoA class)

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Physical state

White powder

Related substances & organisms

glyphosate

glyphosate-diammonium

glyphosate-trimesium

glyphosate-sesquisodium

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Monsanto

Example products using this active

Roundup

Formulation and application details

Wide range of formulations available

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

1050000

High

Solubility - In organic solvents at 20 °C (mg l⁻¹)

19860

Methanol

Hexane

Toluene

Acetone

Melting point (°C)

143

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

282

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

6.92 X 10^-05

Calculated

Log P

-4.16

Low

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

2.18

pKa2=5.77

Vapour pressure at 20 °C (mPa)

0.007

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

4.6 X 10^-10

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

pH7: 200nm=279
pH2: 200nm=233
pH10: 200nm=534

Surface tension (mN m⁻¹)

72.8

at 20 °C 96.7%

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

16.11

as glyphosate

Non-persistent

DT₅₀ (lab at 20 °C)

16.11

as glyphosate

Non-persistent

DT₅₀ (field)

6.45

as glyphosate

Non-persistent

DT₉₀ (lab at 20 °C)

296.82

as glyphosate

Persistent

DT₉₀ (field)

120

as glyphosate

DT₅₀ modelling endpoint

Note

Data for glyphosate acid EFSA 2021 RAR: Lab studies DT₅₀ range 0.7-78.9 days, DT₉₀ range 14.9-1660 days, Soils=10; field studies DT₅₀ range 1.1-13.7 days, DT₉₀ range 54.4-201 days, Soils =6

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Note

Water-sediment DT₅₀ (days)

20.8

as glyphosate

Fast

Water phase only DT₅₀ (days)

9.9

as glyphosate

Moderately fast

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d

Non-mobile

K_oc

6920

Notes and range

Freundlich

K_f

70.85

as glyphosate

Non-mobile

K_foc

5436

¹/_n

0.69

Notes and range

Data for glyphosate acid EFSA 2021 RAR: K_f range 18.1-166.4 mL g⁻¹, K_foc range 1031-9615, ¹/_n range 0.540-0.777, Soils=10

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

0.21

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

5.44 X 10^-03

Calculated

Note

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Non-mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

Bio-concentration factor

BCF (l kg⁻¹)

CT₅₀ (days)

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

glyphosate (Ref: MON 0573)

Major fraction

1.0

aminomethylphosphonic acid

Major fraction

0.469

Known groundwater metabolites

Metabolite

EC SANCO/221/2000 relevancy

ADI (mg kg⁻¹ bodyweight day⁻¹)

WHO drinking water guidance value (μg L⁻¹ day⁻¹)

glyphosate (Ref: MON 0573)

Relevant

aminomethylphosphonic acid

Relevant

Other known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2000

Colinus virginianus as glyphosate

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

116

Anas platyrhynchos as glyphosate

Moderate

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

> 5600

Eisenia foetida as glyphosate

Low

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

21.31

Eisenia foetida as glyphosate

Moderate

Soil micro-organisms

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

587

Folsomia candida as glyphosate

Non-target plants

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Apis mellifera as glyphosate

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 104

Apis mellifera as glyphosate

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic as 10-day LDD₅₀ µg bee⁻¹ day⁻¹

> 179

Apis mellifera as glyphosate

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps)

Beneficial insects (Predatory mites)

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 1001

Oncorhynchus mykiss

Low

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

> 8.8

Zebra Danio

Moderate

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 5.16

Danio rerio Eggs

Moderate

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

> 471

Daphnia magna

Low

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

42.9

Daphnia magna

Low

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

> 26

Ceriodaphnia dubia

Moderate

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

88.4

Lemna paucicostata

Low

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

> 72.9

Scenedesmus subspicatus

Low

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.0

Rat 4 hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.5

Dog & Rat SF=100 as Glyphosate

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

1.5

Rabbit SF=100 as Glyphosate

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

0.3

Rabbit SF=500 as Glyphosate

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.1

Dog & Rabbit SF=500 as Glyphosate

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

Risks to bystanders and residents considered low

Occupational

PPE/PPC recommended to reduce risks

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

GB MRL amended July 2021

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Rapid and extensive - approx 90% in 24hrs mainly via faeces

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

No data found

General human health issues

IARC Group 2A carcinogen; US EPA - no evidence to support classification as human carcinogen; EFSA - inconclusive data for cancer in humans
Possible bladder and liver toxicant

Handling issues

Property

Value and interpretation

General

IMDG Transport Hazard Class 9
Not oxidising or explosive
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Health: H318
Environment: H411

WHO Classification

III (Slightly hazardous)

UN Number

UN3077

Waste disposal & packaging

Packaging Group III (minor danger)

Shelf-life, storage, stability and reactivity

Chemically stable under standard ambient conditions

TRANSLATIONS

Language

Name

English

glyphosate-isopropylamine

French

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Danish

Italian

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Polish

Swedish

Hungarian

Dutch

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Record last updated:	02/03/2024
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242