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GET ADDITIONAL DATA HERE!

glyphosate (Ref: MON 0573)
** CP 67573 ** sulfosate ** 2-[(phosphonomethyl)amino]acetic acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Glyphosate is a non-selective common and effective herbicide. It is highly soluble in water, relatively volatile and does not normally leach to groundwater. It is not persistent in soils but may be in aquatic systems under certain conditions. It is moderately toxic to humans and a skin and eye irritant. It is moderately toxic to birds, most aquatic organisms, earthworms and honeybees.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for glyphosate

Description: A broad-spectrum herbicide used in a wide range of cropping, utility and industrial situations to for broad-spectrum control of weeds and grasses

Example pests controlled: Annual and perennial weeds, Broad-leaved weeds, Grasses

Example applications: Agriculture including cereals; Soybeans, Glyphosate tolerant crops; Horticulture; Forestry; Domestic gardens, lawns

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1971, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Germany/Slovakia
Date inclusion expires 15/12/2022
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C3H8NO5P
Canonical SMILES C(C(=O)O)NCP(=O)(O)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) XDDAORKBJWWYJS-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Phosphonoglycine
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - Formaldehyde < 1 g/kg; N-nitroso-glyphosate < 1 mg/kg
Substance origin Synthetic
Mode of action Broad-spectrum, systemic, contact action translocated and non-residual. Inhibition of EPSP synthase.
CAS RN 1071-83-6
EC number 213-997-4
CIPAC number 284
US EPA chemical code 417300
PubChem CID 3496
Molecular mass (g mol-1) 169.1
PIN (Preferred Identification Name) -
IUPAC name N-(phosphonomethyl)glycine
CAS name N-(phosphonomethyl)glycine
Other status information Risk of herbicide resistance developing - anti-resistance management required; PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) G
Herbicide Resistance Classification (WSSA) 9
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Eleusine indica
Lolium rigidum
Amaranthus palmeri
Euphorbia heterophylla
Physical state Colourless crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer Environ
  • Dow AgroSciences
  • Headland
  • Makhteshim-Agan
  • Monsanto
  • Nufarm UK
  • Syngenta
Example products using this active
  • Asteroid
  • Envision
  • Touchdown
  • Glyfos
  • Glyfos Daker
  • Glyphosate 360
  • Glyphogan
  • Kernel
  • Manifest
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for glyphosate

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 10500 A3 High
Solubility - In organic solvents at 20oC (mg l-1) 0.6 A5 - Acetone -
0.6 A5 - Xylenes -
10 A5 - Methanol -
0.6 A5 - Ethyl acetate -
Melting point (oC) 189.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 200 L3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 6.31 X 10-04 Calculated -
Log P -3.2 A5 - @ 25 DegC Low
Bulk density (g ml-1)/Specific gravity 1.71 A5 -
Dissociation constant (pKa) at 25oC 2.34 A5 -
Note: Strong acid, pKa(2) = 5.73
Vapour pressure at 20oC (mPa) 0.0131 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.10 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.25 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 290nm=10; No max in range 200-340 nm A5 -
Surface tension (mN m-1) 72.2 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 15.0 A5 Non-persistent
DT50 (lab at 20oC) 15.0 A5 Non-persistent
DT50 (field) 23.79 A5 Non-persistent
DT90 (lab at 20oC) 215.2 A5 -
DT90 (field) 169.68 A5 -
DT50 modelling endpoint - - -
Note EU Dossier (2015) Lab studies DT50 range 1.0-67.7 days, DT90 range 9.3-1661 days, Soils=15; field studies DT50 range 5.7-40.9 days, DT90 range 66.9-386.6 days, Soils = 8
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 10.6 R4 -
Note Published literature RL50 range 2.2-17.0 days, 6 field crops, various matrices, n=6
Aqueous photolysis DT50 (days) at pH 7 Value 69 A5 Stable
Note pH sensitive: DT50 33 days at pH 5, 77 days at pH 9
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 8 at 25 degC
Water-sediment DT50 (days) 74.5 A5 Moderately fast
Water phase only DT50 (days) 9.9 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 209.4 A5 Slightly mobile
Koc 1424
Notes and range EU dossier (2015) Kd range 5.0-510 mL/g, koc range 884-50660 mL/g, Soils=9
Freundlich Kf 226.3 A5 Non-mobile
Kfoc 16331
1/n 0.86
Notes and range EU dossier (2015) Kf range 9.4-700 mL/g, Kfoc range 1600-60000, 1/n range 0.72-1.16, Soils=11
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
aminomethylphosphonic acid This metabolite may cause environmental pollution, click here for further information Soil   0.538   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
N-acetyl-N-(phosphonomethyl)glycine N-acetyl-glyphosate Plants; Livestock - -
(acetamidomethyl)phosphonic acid N-acetyl-AMPA Plants; Livestock - -
(hydroxymethyl)phosphonic acid HMPA Water - -


ECOTOXICOLOGY

for glyphosate

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 0.5 F4 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 150 A5 Rat Moderate
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 4640 mg kg feed-1 A4 Unknown species -
Fish - Acute 96 hour LC50 (mg l-1) 38.0 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 25 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 40 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 30 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 40.0 F4 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 12 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 4.4 F4 Scenedesmus quadricauda Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 2 Q2 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) 100 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 5600 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) > 28.8 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 5760 >
A5 Aphidius rhopalosiphi
-
% Effect 25
6
Mortality
Fertility
Dose: 3.72 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 4320 >
A5 Typhlodromus pyri
-
% Effect 30
0
Mortality
Fertility
Dose: 3.6 kg ha-1
A5 Typhlodromus pyri, lifecycle
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 18 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for glyphosate

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.3 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.5 A5 rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.1 A3 Rabbit, SF=500 -
Dermal penetration studies (%) 1.0 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Risks to bystanders and residents considered low
Occupational PPE/PPC recommended to reduce risks
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues IARC group 2A carcinogen; USEPA - no evidence to support classification as human carcinogen
Possible bladder and liver toxicant
May cause serious eye damage
Endocrine issues - Disruption of aromatase activity

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is usually 9
Not oxidising or explosive
Corrosive
CLP classification 2013 Handling: GHS05
Health: H318
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R41
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S26, S39, S61
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for glyphosate

Language Name
English glyphosate
French glyphosate
German Glyphosat
Danish glyphosat
Italian glifosate
Spanish glifosato
Greek glyphosate
Slovenian glifosat
Polish glifosat
Swedish glyfosat
Hungarian glifozat
Dutch glyfosaat

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk