Glyphosate (Ref: MON 0573)

Glyphosate (Ref: MON 0573)	Last updated: 12/01/2021
(Also known as: CP 67573; sulfosate; 2-[(phosphonomethyl)amino]acetic acid)

SUMMARY

Glyphosate is a non-selective common and effective herbicide. It is highly soluble in water, relatively volatile and does not normally leach to groundwater. It is not persistent in soils but may be in aquatic systems under certain conditions. It is moderately toxic to humans and a skin and eye irritant. It is moderately toxic to birds, most aquatic organisms, earthworms and honeybees.

GENERAL INFORMATION

Description

A broad-spectrum herbicide used in a wide range of cropping, utility and industrial situations to for broad-spectrum control of weeds and grasses

Example pests controlled

Annual and perennial weeds, Broad-leaved weeds, Grasses

Example applications

Agriculture including cereals; Soybeans, Glyphosate tolerant crops; Horticulture; Forestry; Domestic gardens, lawns

Efficacy & activity

Availability status

Current

Introduction & key dates

1971, first reported

UK regulatory status

UK COPR regulatory status

Approved

Date COPR inclusion expires

15/12/2025

UK LERAP status

Buffer probably required in UK - see product label

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Germany/Slovakia

Date EC 1107/2009 inclusion expires

15/12/2022

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓	✓	✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓	✓	✓	✓	✓	✓	✓	✓	✓

Also used in

Australia, USA

Chemical structure

Isomerism

Chemical formula

C₃H₈NO₅P

Canonical SMILES

C(C(=O)O)NCP(=O)(O)O

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

XDDAORKBJWWYJS-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9)

2D structure diagram/image available?

Yes

Cambridge Crystallographic Data Centre diagrams

Common Name	Relationship	Link
glyphosate	-

General status

Pesticide type

Herbicide

Substance group

Phosphonoglycine

Minimum active substance purity

950 g kg⁻¹

Known relevant impurities

EU dossier - Formaldehyde < 1 g kg⁻¹; N-nitroso-glyphosate < 1 mg kg⁻¹

Substance origin

Synthetic

Mode of action

Broad-spectrum, systemic, contact action translocated and non-residual. Inhibition of EPSP synthase.

CAS RN

1071-83-6

EC number

213-997-4

CIPAC number

284

US EPA chemical code

417300

PubChem CID

3496

Molecular mass

169.1

PIN (Preferred Identification Name)

IUPAC name

N-(phosphonomethyl)glycine

CAS name

N-(phosphonomethyl)glycine

Other status information

Risk of herbicide resistance developing - anti-resistance management required; PAN listed Highly Hazardous Chemical

Relevant Environmental Water Quality Standards

Herbicide Resistance Classification (HRAC)

Herbicide Resistance Classification (WSSA)

Insecticide Resistance Classification (IRAC)

Not applicable

Fungicide Resistance Classification (FRAC)

Not applicable

Examples of recorded resistance

Eleusine indica, Lolium rigidum, Amaranthus palmeri, Euphorbia heterophylla

Physical state

Colourless crystals

Related substances & organisms

diflufenican

ethoxylated tallow amine

polyacrylamide

8-hydroxyquinoline

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Asteroid
Envision
Touchdown
Glyfos
Glyfos Daker
Glyphosate 360
Glyphogan
Kernel
Manifest

Example products using this active

Bayer Environ
Dow AgroSciences
Headland
Makhteshim-Agan
Monsanto
Nufarm UK
Syngenta

Formulation and application details

Often supplied as a soluble concentrate that is mixed with water and applied as a spray

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

10500

High

Solubility - In organic solvents at 20 °C (mg l⁻¹)

0.6

Acetone

0.6

Xylenes

Methanol

0.6

Ethyl acetate

Melting point (°C)

189.5

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

200

Flashpoint (°C)

Not expected to self ignite; Not highly flammable

Octanol-water partition coefficient at pH 7, 20 °C

6.31 X 10^-04

Calculated

Log P

-3.2

at 25 °C

Low

Bulk density (g ml⁻¹)

1.71

Dissociation constant pKa) at 25 °C

2.34

Strong acid, pKa(2) = 5.73

Vapour pressure at 20 °C (mPa)

0.0131

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

2.10 X 10^-07

Non-volatile

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

290nm=10; No max in range 200-340 nm

Surface tension (mN m⁻¹)

72.2

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

15.0

Non-persistent

DT₅₀ (lab at 20 °C)

15.0

Non-persistent

DT₅₀ (field)

23.79

Non-persistent

DT₉₀ (lab at 20 °C)

215.2

Persistent

DT₉₀ (field)

169.68

DT₅₀ modelling endpoint

Note

EU Dossier (2015) Lab studies DT₅₀ range 1.0-67.7 days, DT₉₀ range 9.3-1661 days, Soils=15; field studies DT₅₀ range 5.7-40.9 days, DT₉₀ range 66.9-386.6 days, Soils = 8

Dissipation rate RL₅₀ on plant matrix

Value

Note

Dissipation rate RL₅₀ on and in plant matrix

Value

10.6

Note

Published literature RL₅₀ range 2.2-17.0 days, 6 field crops, various matrices, n=6

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Stable

Note

pH sensitive: DT₅₀ 33 days at pH 5, 77 days at pH 9

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable pH 5 to pH 8 at 25 °C

Water-sediment DT₅₀ (days)

74.5

Moderately fast

Water phase only DT₅₀ (days)

9.9

Moderately fast

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d

209.4

Slightly mobile

K_oc

1424

Notes and range

EU dossier (2015) K_d range 5.0-510 mL g⁻¹, koc range 884-50660 mL g⁻¹, Soils=9

Freundlich

K_f

226.3

Non-mobile

K_foc

16331

¹/_n

0.86

Notes and range

EU dossier (2015) K_f range 9.4-700 mL g⁻¹, K_foc range 1600-60000, ¹/_n range 0.72-1.16, Soils=11

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

-0.29

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

5.35 X 10^-03

Calculated

Note

Estimated concentrations of chemicals with Koc values greater than 9995 ml g⁻¹ are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Key metabolites

Metabolite

Formation medium

Estimated maximum occurrence fraction

1107/2009 relevancy

aminomethylphosphonic acid

Soil

0.538

Major fraction, Relevant

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

Metabolising enzymes

N-acetyl-N-(phosphonomethyl)glycine

N-acetyl-glyphosate

Plants; Livestock

(acetamidomethyl)phosphonic acid

N-acetyl-AMPA

Plants; Livestock

(hydroxymethyl)phosphonic acid

HMPA

Water

ECOTOXICOLOGY

Property

Value

Source; quality score; and other information

Interpretation

Bio-concentration factor

BCF (l kg⁻¹)

0.5

Whole fish

Low potential

CT₅₀ (days)

Not available

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

150

Rat

Moderate

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

351

Unknown species Reproductive NOAEL

Low

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2250

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 4640 mg kg feed⁻¹

Unknown species

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

96.3

Colinius virginianus

Moderate

Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

38.0

Oncorhynchus mykiss

Moderate

Fish - Chronic 21 day NOEC (mg l⁻¹)

1.0

Brachydanio rerio

Moderate

Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Daphnia magna

Moderate

Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

12.5

Daphnia magna

Low

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

40.0

Americamysis bahia

Moderate

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

Lemna gibba

Low

Non-target plants

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

19.0

Pseudokirchneriella subcapitata

Low

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Unknown species

Low

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

100

Apis mellifera

Moderate

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other pollinators (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other pollinators (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

> 5600

Eisenia foetida

Low

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

> 28.8

Eisenia foetida

Moderate

Other soil macro-organisms

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

587

Folsomia candida

Other arthropod (1)

LR₅₀ g ha⁻¹

5760

>
Aphidius rhopalosiphi

% Effect

25 / 6

Mortality / Fertility [Dose: 3.72 kg ha⁻¹]
Aphidius rhopalosiphi adult

Other arthropod (2)

LR₅₀ g ha⁻¹

4320

>
Typhlodromus pyri

% Effect

30 / 0

Mortality / Fertility [Dose: 3.6 kg ha⁻¹]
Typhlodromus pyri lifecycle

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 18 kg ha⁻¹

Mesocosm study data

NOEAEC mg l⁻¹

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.0

Rat 4 hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.5

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.5

rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.1

Rabbit SF=500

Dermal penetration studies (%)

1.0

Dangerous Substances Directive 76/464

Exposure Routes

Public

Risks to bystanders and residents considered low

Occupational

PPE/PPC recommended to reduce risks

European MRLs

EU MRL pesticide database

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

IARC group 2A carcinogen; USEPA - no evidence to support classification as human carcinogen
Possible bladder and liver toxicant
May cause serious eye damage
Endocrine issues - Disruption of aromatase activity

Handling issues

Property

Value and interpretation

General

IMDG Transport Code is usually 9
Not oxidising or explosive
Corrosive

CLP classification 2013

Handling: GHS05
Health: H318
Environment: H411

EC Risk Classification

Xn - Harmful: R41
N - Dangerous for the environment: R51, R53

EC Safety Classification

S2, S26, S39, S61

WHO Classification

III (Slightly hazardous)

UN Number

Variable with product, usually 3077 or 3082

Waste disposal & packaging

Packaging Group III (minor danger)

TRANSLATIONS

Language

Name

English

glyphosate

French

glyphosate

German

Glyphosat

Danish

glyphosat

Italian

glifosate

Spanish

glifosato

Greek

glyphosate

Polish

glifosat

Swedish

glyfosat

Hungarian

glifozat

Dutch

glyfosaat

Record last updated:	12/01/2021
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242