Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

flutriafol (Ref: PP 450)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for flutriafol

Description: A curative and preventative conazole fungicide used to control leaf and ear diseases usually in cereals

Example pests controlled: Leaf and ear diseases

Example applications: Cereals including corn; Soybeans; Apples

Efficacy & activity: Wheat/Mildew=Low; Wheat/Septoria=Low; Wheat/Rust=Low; Soybean/Anthracnose=High; Soybean/Brown spot=High; Soybean/Leaf blight=Moderate; Soybean/Rust=High; Soybean/White mould=Moderate

Availability status: Current

Introduction & key dates: 1981

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Slovakia/UK
Date inclusion expires 31/05/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Brazil, South Africa, Russia, Tanzania

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule existing in the R- and S-forms
Chemical formula C16H13F2N3O
Canonical SMILES C1=CC=C(C(=C1)C(CN2C=NC=N2)(C3=CC=C(C=C3)F)O)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) JWUCHKBSVLQQCO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C16H13F2N3O/c17-13-7-5-12(6-8-13)16(22,9-21-11-19-10-20-21)14-3-1-2-4-15(14)18/h1-8,10-11,22H,9H2
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 920 g/kg
Known relevant impurities EU dossier - dimethyl sulphate: <0.01%; dimethylformamide:<0.1%; methanol: <0.1%
Substance origin Synthetic
Mode of action Broad-spectrum, systemic, contact action with eradicant and protective properties. Sterol biosynthesis inhibitor.
CAS RN 76674-21-0
EC number -
CIPAC number 436
US EPA chemical code 128940
PubChem CID 91727
Molecular mass (g mol-1) 301.29
PIN (Preferred Identification Name) -
IUPAC name (RS)-2,4'-difluoro-α-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol
CAS name α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol
Other status information A marine pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Headland
  • Syngenta
Example products using this active
  • Beret Multi
  • Consul
  • Impact Excel
  • Pointer
UK LERAP status None
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for flutriafol

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 95.0 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 116000 A5 - Acetone -
300 C4 - Hexane -
115000 A5 - Methanol -
10000 A5 - Xylene -
Melting point (oC) 130 A5 -
Boiling point (oC) - - -
Degradation point (oC) 270 A4 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1002 Calculated -
Log P 2.3 A5 Low
Bulk density (g ml-1)/Specific gravity 1.41 L3 -
Dissociation constant (pKa) at 25oC 2.3 A5 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 4.0 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.27 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 5.40 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 9.12 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 No absorption above 290nm A5 -
Surface tension (mN m-1) 68.7 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 1358 B5 Very persistent
DT50 (lab at 20oC) 1587 A5 Very persistent
DT50 (field) 860 A5 Very persistent
DT90 (lab at 20oC) 5690 A5 -
DT90 (field) 3827 A5 -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 672-3492 days, DT90 range 2231-11599 days; Other Lab studies - degradation very slow, field study DT50 range 405-3836 days, DT90 range 690-13583 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 11.7 R3 -
Note Wheat, whole plant, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable Q3 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable B1 -
Note -
Water-sediment DT50 (days) Stable B3 -
Water phase only DT50 (days) 36 B3 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 3.96 A5 Moderately mobile
Kfoc 205
1/n 0.906
Notes and range EU dossier Kf range 1.3-9.75 mL/g, Kfoc range 104-395 mL/g, 1/n range 0.88-0.97
pH sensitivity Slowly decreasing sorption with increasing pH - not significant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
triazolyl alanine TA Plant - -
1H-1,2,4-triazol-1-ylacetic acid
(Ref: CGA 142856)
Note: B3
TAA; triazolyl acetic acid Plant - -


ECOTOXICOLOGY

for flutriafol

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk E3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 1140 B5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - B5 Rat -
(ppm diet) 2 -
Birds - Acute LD50 (mg kg-1) 616 A4 Alectoris rufa Moderate
Birds - Short term dietary (LC50/LD50) 435 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 33.0 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 6.2 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 67 B5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.55 Q2 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.65 A5 Lemna gibba Moderate
Non-target plants > 134 A4 Unknown species
Seedling emergence, ER50
as g/ha
-
> 134 A4 Unknown species
Vegetative vigour, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 12 B5 Raphidocelis subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 50 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 2.0 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 6.1 A3 Eisenia foetida, 56 days, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 204.5 A5 Typhlodromus pyri -
% Effect - - -
Other arthropod (2) LR50 g ha-1 1125 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 1.67 kg/kg soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for flutriafol

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 1140 B5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 1000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.2 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 UK ACP 1999 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.05 A5 Dog, SF=100 -
Dermal penetration studies (%) 0.3-10.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable risk for proposed uses
Occupational Acceptable risk for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Possible liver toxicant
May cause anaemia
Endocrine issues - Weak estrogen inhibition

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
Not explosive or oxidising
IMDG Transport Code 9
CLP classification 2013 Health: H340, H360fd
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R63
Xn - Harmful: R20/21/22
N - Dangerous for the environment: R52, R53
EC Safety Classification Click here to view information omn the EU safety phrases S22, S24, S25
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (Minor danger)


TRANSLATIONS

for flutriafol

Language Name
English flutriafol
French flutriafol
German Flutriafol
Danish flutriafol
Italian flutriafol
Spanish flutriafol
Greek -
Slovenian flutriafol
Polish flutriafol
Swedish -
Hungarian flutriafol
Dutch -

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk