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** manzeb ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

for mancozeb

Description: A fungicide for control of a wide range of pathogens including blights, mildews and scabs on potatoes and other crops

Introduction: 1961, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Italy
Date inclusion expires 30/06/2016

Approved for use () or known to be used () in the following European countries:




























Also registered in: Australia, USA

General status:
Pesticide type Fungicide
Substance group Carbamate
Substance origin Synthetic
Mode of action Broad spectrum, non-systemic, contact with protective action, acts by distrupting lipid metabolism. Multi-site activity.
CAS RN 8018-01-7
Alternative/old CAS RN formerly 8065-67-6
EC number 006-076-00-1
CIPAC number 34
US EPA chemical code 014504
Chiral molecule No
Chemical formula (C4H6MnN2S4)x(Zn)y
SMILES [Mn+2].[Zn+2].[S-]C(=S)NCCNC(=S)[S-].[S-]C(=S)NCCNC([S-])=S
International Chemical Identifier key (InChIKey) CHNQZRKUZPNOOH-UHFFFAOYSA-J
International Chemical Identifier (InChI) InChl=1S/2C4H8N2S4.Mn.Zn/c2*7-3(8)5-1-2-6-4(9)10;;/h2*1-2H2,(H2,5,7,8)(H2,6,9,10);;/q;;2*+2/p-4
Structure diagram/image available? Yes
Molecular mass (g mol-1) 271.3
PIN (Preferred Identification Name) -
IUPAC name manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt
CAS name [[2-[(dithiocarboxy)amino]ethyl]carbamodithioato]](2-)-kS,kS']manganese mixture with [[2-[(dithiocarboxy)amino]ethyl]carbamodithioato]](2-)-kS,kS']zinc
Other status information Marine Pollutant
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) M3
Physical state Grey to yellow coloured powder
Related substances & organisms

Property Value
Example manufacturers & suppliers of products using this active
  • AgriGuard
  • Certis
  • Dow AgroSciences
  • DuPont
  • Headland
  • Interfarm
  • Nufarm
  • Sipcam
  • Syngenta
Example products using this active
  • Fubol Gold
  • Dithane Dry Flowable
  • Dithane 945
  • Karamate DryFlo
  • Manzate 75WG
  • Matilda WG
  • Penncozeb
UK LERAP status LERAP Category B (may vary across mixtures)
Formulation and application details Often supplied as wettable granules and powders that are mixed with water and used as a spray.


for mancozeb

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 6.2 G4 Low
Solubility - In organic solvents at 20oC (mg l-1) Insoluble A4 - Most organic solvents -
Melting point (oC) Decomposes before melting A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 172 L3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.14 X 1001 Calculated -
Log P 1.33 A5 Low
Bulk density (g ml-1)/Specific gravity 1.98 A5 -
Dissociation constant (pKa) at 25oC 10.3 A5 -
Note: Very weak acid
Vapour pressure at 25oC (mPa) 0.013 A5 Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1) 5.90 X 10-04 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 1.76 X 10-10 Q2 Non-volatile
GUS leaching potential index -1.00 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 2.84 X 10-06 Calculated -
Note -
Potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 0.1 A5 Non-persistent
DT50 (lab at 20oC) 0.1 A5 Non-persistent
DT50 (field) 18 H4 Non-persistent
DT90 (lab at 20oC) 0.5 A5 -
DT90 (field) - - -
Note EU dossier lab studies DT50 range 1-3 hours, Dt90 range 2- 25 hours
Aqueous photolysis DT50 (days) at pH 7 Value Stable A3 Stable
Note Not a significant route of degradation
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 1.3 A4 Non-persistent
Note pH variable: DT50 2-36 hours at pH 5, 5.5-55 hours at pH 7, 15 hours at pH 9
Water-sediment DT50 (days) 76 Q3 Moderately fast
Water phase only DT50 (days) 0.2 A5 Fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd 9.7 A5 Slightly mobile
Koc 998
Notes and range EU dossier Kd range 7.26-11.67 mL/g, Koc range 363-2334 mL/g, Soils=4
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
ethylenethiourea Soil   0.031   Minor fraction, Relevant
ethyleneurea Soil   0.085   Minor fraction, Relevant
ethylene bisisothiocyanate sulphide Soil   0.082   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
ethylene thiuram disulphide ETD Soil Very low -


for mancozeb

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF 3.2 A5 Low potential
CT50 (days) Not available -
Bioaccumulation potential - Calculated Low
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A4 Median across species Moderate
Birds - Short term dietary (LC50/LD50) > 860 mg kg bw-1 day-1 A4 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.074 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.0022 A4 Oncorhynchus mykiss, 34 day NOEC -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.073 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0073 A5 Daphnia magna -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.044 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) 140.6 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 299.1 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 20.0 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 75 Long term effect
Dose: 36 kg ha-1
A5 Typhlodromus pyri, adult
Moderately harmful
Other arthropod (2) LR50 g ha-1 - - -
% Effect -0.4 Mortality
Dose: 2.6 kg ha-1
A5 Aphidius rhopalosiphi
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
Dose: 4.2 kg ha-1
Mesocosm study data NOEAEC mg l-1 0.032 A5 Invertebrates and phytoplankton -
NOEAEC mg l-1 - - -


for mancozeb

Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.14 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.6 A5 Rat -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.035 A5 -
Dermal penetration studies (%) 0.11-0.24 A5 concentration dependant -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Examples of European MRLs (mg kg-1) Value Currants, gooseberries, citrus and lettuce: 5.0; Tomatoes and pome fruit: 3.0; Apricots, nectarines, peaches, grapes, strawberries, barley grains and oat grains: 2.0; Brassicas, beans (with pods), peas (with pods), cherries, plums, rye grains and wheat grains: 1.0; Onions, garlic, cucumbers, melons (not watermelons), pumpkins, summer squash and celery: 0.5; Carrots: 0.2; Potatoes, beans (edible part) and peas (edible part): 0.1; Other vegetables, other fruit and other cereal grains: 0.05
Note Current May 2007. Expressed as carbon disulphide.
For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

General human health issues May cause ovarian hyperthropy
Possible thyroid toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Not explosive
IMDG Transport Code is usually 9
CLP classification 2013 -
EC Risk Classification Reproduction risk category 3: R63
Xn - Harmful: R43
N - Dangerous for the environment: R50
EC Safety Classification S2, S36/37, S46, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Packaging Group III (minor danger)


for mancozeb

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Record last updated: Saturday 13 December 2014