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metiram (Ref: BAS 222F)
** carbatene ** metirame ** zinc metiram ** polyram ** FMC 9102 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for metiram

Description: A fungicide used to control a wide range of fungal diseases including damping-off

Example pests controlled: Scab; Downey mildew; Blight

Example applications: Top fruit; Grapes; Potatoes; Tomatoes; Onion & garlic; Celeriac; Cucubits; Lettuce; Field crops; Herbs; Ornamentals; Asparagus; Cotton

Efficacy & activity: Efficiacy has been demonstrated by its long-term and extensive use in the EU and many other countries as well as via field trials

Availability status: Current

Introduction & key dates: 1958, introduced Germany

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Italy/UK
Date inclusion expires 31/01/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula (C16H33N11S16Zn3)x
Canonical SMILES C(CNC(=S)[S-])NC(=S)S.C(CNC(=S)[S-])NC(=S)S.[NH2-].[Zn]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) VHQATEKXKUZBLS-UHFFFAOYSA-L
International Chemical Identifier (InChI) InChI=1S/C4H8N2S4.H3N.Zn/c7-3(8)5-1-2-6-4(9)10;;/h1-2H2,(H2,5,7,8)(H2,6,9,10);1H3;/q;;+2/p-2
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Carbamate
Minimum active substance purity 840 g/kg
Known relevant impurities EU dossier - ethylene thiourea my not be toxicologically relevant
Substance origin Synthetic
Mode of action Broad spectrum, non-systemic with protective action. Multi-site activity.
CAS RN 9006-42-2
Alternative/old CAS RN 9063-14-3
EC number -
CIPAC number 478
US EPA chemical code 014601
PubChem CID No data
Molecular mass (g mol-1) (1088.6)x
PIN (Preferred Identification Name) -
IUPAC name zinc ammoniate ethylenebis(dithiocarbamate) - poly(ethylenethiuram disulfide)
CAS name metiram
Other status information Marine pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) M3
Examples of recorded resistance -
Physical state Yellow powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • FMC
Example products using this active
  • Carbatene
  • Polyram
  • Polyram-Combi
UK LERAP status None
Formulation and application details Usually supplied as a wettable powder.


ENVIRONMENTAL FATE

for metiram

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 100 A3 - Methanol -
100 A3 - Acetone -
100 A3 - Toluene -
100 A3 - Ethyl acetate -
Melting point (oC) 156 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 156 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.14 X 1000 Calculated -
Log P 0.33 A5 Low
Bulk density (g ml-1)/Specific gravity 1.86 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.0 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.0 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.22 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 259nm = 64000, 281nm = 48000, 29 nm = 30000 A5 -
Surface tension (mN m-1) 71.8 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 1.3 A5 Non-persistent
DT50 (lab at 20oC) 1.3 A5 Non-persistent
DT50 (field) 7 A3 Non-persistent
DT90 (lab at 20oC) 4.7 A5 -
DT90 (field) 14 A3 -
DT50 modelling endpoint - - -
Note EU 2017 dossier lab studies DT50 (normalised) range 0.5-2.2 days, DT90 range 1.7-17.3 days, Soils=5, EU 2001 Dossier field studies DT50 ~7days, DT90 <14 days; Other sources: 20 days (DW4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.3 A5 Fast
Note 6.3 hours in continuous irradiation, 0.6 days central Europe scenario, March
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 0.1 A5 Non-persistent
Note pH sensitive
Water-sediment DT50 (days) 0.2 A5 Fast
Water phase only DT50 (days) 0.4 A5 Fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 8800 A5 Non-mobile
Koc 903012
Notes and range EU 2017 dossier Kd range 4553-11891 mL/g, Koc range 393044-1801689mL/g, Soils=5
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
ethylenethiourea This metabolite may cause environmental pollution, click here for further information Soil   0.112   Major fraction, Relevant
ethylene bisisothiocyanate sulphide This metabolite may cause environmental pollution, click here for further information Soil   0.257   Major fraction, Relevant
ethyleneurea Soil   0.069   Minor fraction, Relvant
2,3,7,8-tetrahydroiimidazo(2.1-b:1',2'-e)(1,3,5)thiadizine-5-thione This metabolite may cause environmental pollution, click here for further information Soil   0.135   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
carbimid
(Ref: )
Note: Major fraction, Relevant
- Soil - -
- TDIT Soil 0.135 -
- hydantoin Water - -


ECOTOXICOLOGY

for metiram

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 3.2 Q3 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 50 G3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2150 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) 853 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.336 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.022 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.584 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0043 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) > 144 A5 Chironomus tentans Low
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.221 A5 Chironomus tentans Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 21.6 A5 Chironomus tentans Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 0.517 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.191 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 80 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 80 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) > 23.3 A5 Eisenia foetida, 56day Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 14 Lethal
Dose: 4 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Lethal
Dose: 0.7 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 48 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for metiram

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.7 A5 Rat 4 hr, (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.03 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.4 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) None allocated A5 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.016 A5 Dog, SF=100 -
Dermal penetration studies (%) 0.2-3.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues USEPA - probable human carcinogen
Possible thyroid toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317, H373
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
Xi - Irritant: R38
EC Safety Classification Click here to view information omn the EU safety phrases S2, S13, S37, S46
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packging Group III (minor danger)


TRANSLATIONS

for metiram

Language Name
English metiram
French métirame zinc
German Metiram
Danish metiram
Italian metiram
Spanish metiram
Greek -
Slovenian metiram
Polish metiram
Swedish -
Hungarian metiram
Dutch -

Record last updated: Wednesday 07 November 2018
Contact: aeru@herts.ac.uk