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2-hydroxyquinoxaline
** 2-quinoxalinone ** quinoxalin-2-ol ** HQO ** Translations |
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Environmental Fate - Ecotoxicology - Human Health
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GENERAL INFORMATION
Description:
Chemical transformation product
Availability status:
Not applicable
Introduction & key dates:
Not applicable
EC Regulation 1107/2009 (repealing 91/414):
Status |
Not applicable |
Dossier rapporteur/co-rapporteur |
Not applicable |
Date inclusion expires |
Not applicable |
EU Candidate for substitution (CfS) |
Not applicable |
Listed in EU database |
No |
Approved for use (
) or known to be used (
) in the following European countries:
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |

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Chemical structure:
Isomerism |
- |
Chemical formula |
C8H6N2O |
Canonical SMILES |
C1=CC=C2C(=C1)NC(=O)C=N2 |
Isomeric SMILES |
No data |
International Chemical Identifier key (InChIKey) |
FFRYUAVNPBUEIC-UHFFFAOYSA-N |
International Chemical Identifier (InChI) |
InChI=1S/C8H6N2O/c11-8-5-9-6-3-1-2-4-7(6)10-8/h1-5H,(H,10,11) |
2D structure diagram/image available? |
Yes |
General status:
Pesticide type |
Metabolite |
Metabolite Type |
Soil, Animal |
Substance group |
Unclassified |
Minimum active substance purity |
- |
Known relevant impurities |
- |
Substance origin |
Synthetic |
Mode of action |
Not applicable |
CAS RN |
1196-57-2 |
EC number |
214-815-6 |
CIPAC number |
- |
US EPA chemical code |
Not applicable |
PubChem CID |
- |
Molecular mass (g mol-1) |
146.1 |
PIN (Preferred Identification Name) |
- |
IUPAC name |
quinoxoline-2-ol |
CAS name |
2-hydroxyquinoxaline |
Other status information |
- |
Relevant Environmental Water Quality Standards |
- |
Herbicide Resistance Classification (HRAC) |
Not applicable |
Herbicide Resistance Classification (WSSA) |
Not applicable |
Insecticide Resistance Classification (IRAC) |
Not applicable |
Fungicide Resistance Classification (FRAC) |
Not applicable |
Examples of recorded resistance |
- |
Physical state |
- |
Related substances & organisms |
- |
Can be a metabolite of:
Parent |
Formation medium |
Estimated maximum occurrence fraction |
1107/2009 relevancy  |
quinalphos |
Soil |
|
- |
Formulations:
Property  |
Value |
Example manufacturers & suppliers of products using this active now or historically |
|
Example products using this active |
- |
UK LERAP status |
Not applicable |
Formulation and application details |
- |
ENVIRONMENTAL FATE
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Solubility - In water at 20oC (mg l-1) |
16400 |
V3 - @ 25 DegC |
High |
Solubility - In organic solvents at 20oC (mg l-1) |
- |
- |
- |
Melting point (oC) |
271 |
Q2 |
- |
Boiling point (oC) |
- |
- |
- |
Degradation point (oC) |
- |
- |
- |
Flashpoint (oC) |
- |
- |
- |
Octanol-water partition coefficient at pH 7, 20oC |
P |
6.31 X 1000 |
Calculated |
- |
Log P |
0.8 |
V3 |
Low |
Bulk density (g ml-1)/Specific gravity |
1.35 |
Q2 |
- |
Dissociation constant (pKa) at 25oC |
- |
- |
- |
Note: |
Vapour pressure at 20oC (mPa) |
- |
- |
- |
Henry's law constant at 25oC (Pa m3 mol-1) |
0.043 |
V3 |
Non-volatile |
GUS leaching potential index  |
-0.28 |
Calculated |
Low leachability |
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate  |
Value |
5.35 X 10-03 |
Calculated |
- |
Note |
Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW |
Potential for particle bound transport index  |
- |
Calculated |
Medium |
Maximum UV-vis absorption L mol-1 cm-1 |
- |
- |
- |
Surface tension (mN m-1) |
- |
- |
- |
Degradation:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
General biodegradability |
- |
Soil degradation (days) (aerobic) |
DT50 (typical) |
2.5 |
A4 |
Non-persistent |
DT50 (lab at 20oC) |
2.37 |
A3 |
Non-persistent |
DT50 (field) |
- |
- |
- |
DT90 (lab at 20oC) |
9.4 |
A3 |
- |
DT90 (field) |
- |
- |
- |
DT50 modelling endpoint |
- |
- |
- |
Note |
EU dossier Lab studies DT50 range 0.04-5.5 days, DT90 range 3.3-18.2 days - data for the sulphate salt |
Dissipation rate RL50 on plant matrix |
Value |
- |
- |
- |
Note |
- |
Dissipation rate RL50 on and in plant matrix |
Value |
- |
- |
- |
Note |
- |
Aqueous photolysis DT50 (days) at pH 7 |
Value |
- |
- |
- |
Note |
- |
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 |
Value |
- |
- |
- |
Note |
- |
Water-sediment DT50 (days) |
- |
- |
- |
Water phase only DT50 (days) |
- |
- |
- |
Soil adsorption and mobility:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Linear
| Kd |
- |
A3 |
- |
Koc |
- |
Notes and range |
- |
Freundlich
| Kf |
1100 |
A3 |
Non-mobile |
Kfoc |
55500 |
1/n |
1.06 |
Notes and range |
EU dossier Kf range 286-1212 mL/g, Kfoc range 12796-110154 mL/g, 1/n range 0.66-139, Soils=5 - data for the sulphate salt |
pH sensitivity |
- |
ECOTOXICOLOGY
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Bio-concentration factor |
BCF (l kg-1) |
- |
- |
- |
CT50 (days) |
- |
- |
Mammals - Acute oral LD50 (mg kg-1) |
- |
- |
- |
Mammals - Short term dietary NOEL |
(mg kg-1) |
- |
- |
- |
(ppm diet) |
- |
- |
Birds - Acute LD50 (mg kg-1) |
- |
- |
- |
Birds - Short term dietary (LC50/LD50) |
- |
- |
- |
Fish - Acute 96 hour LC50 (mg l-1) |
- |
- |
- |
Fish - Chronic 21 day NOEC (mg l-1) |
- |
- |
- |
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) |
- |
- |
- |
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) |
- |
- |
- |
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) |
- |
- |
- |
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) |
- |
- |
- |
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) |
- |
- |
- |
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) |
- |
- |
- |
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) |
- |
- |
- |
Non-target plants |
- |
- |
- |
- |
- |
- |
Algae - Acute 72 hour EC50, growth (mg l-1) |
- |
- |
- |
Algae - Chronic 96 hour NOEC, growth (mg l-1) |
- |
- |
- |
Honeybees |
Contact acute 48 hour LD50 (μg bee-1) |
- |
- |
- |
Oral acute 48 hour LD50 (μg bee-1) |
- |
- |
- |
Unknown mode acute 48 hour LD50 (μg bee-1) |
- |
- |
- |
Earthworms - Acute 14 day LC50 (mg kg-1) |
- |
- |
- |
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) |
- |
- |
- |
Other soil macro-organisms - e.g. Collembola |
LR50 / EC50 / NOEC / % Effect |
- |
- |
- |
Other arthropod (1) |
LR50 g ha-1 |
- |
- |
- |
% Effect |
- |
- |
- |
Other arthropod (2) |
LR50 g ha-1 |
- |
- |
- |
% Effect |
- |
- |
- |
Soil micro-organisms |
- |
- |
- |
Mesocosm study data |
NOEAEC mg l-1 |
- |
- |
- |
NOEAEC mg l-1 |
- |
- |
- |
HUMAN HEALTH AND PROTECTION
General:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Threshold of Toxicological Concern (Cramer Class)  |
High (class III) |
- |
- |
Mammals - Acute oral LD50 (mg kg-1) |
- |
- |
- |
Mammals - Dermal LD50 (mg kg-1 body weight) |
- |
- |
- |
Mammals - Inhalation LC50 (mg l-1) |
- |
- |
- |
Other Mammal toxicity endpoints |
- |
|
- |
ADI - Acceptable Daily Intake (mg kg-1bw day-1) |
- |
- |
- |
ARfD - Acute Reference Dose (mg kg-1bw day-1) |
- |
- |
- |
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) |
- |
- |
- |
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) |
- |
- |
- |
Dermal penetration studies (%) |
- |
- |
- |
Dangerous Substances Directive 76/464 |
- |
- |
- |
Exposure Limits |
- |
- |
- |
Exposure Routes |
Public |
- |
Occupational |
- |
European MRLs |
Click here for the EU MRL pesticide database |
Drinking Water Standards |
- |
- |
- |
Drinking Water MAC (μg l-1) |
- |
- |
- |
Health issues:
Carcinogen |
Mutagen |
Endocrine disrupter |
Reproduction / development effects |
Cholinesterase inhibitor |
Neurotoxicant |
- |
- |
- |
- |
- |
- |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
Eye irritant |
Phototoxicant |
|
- |
- |
- |
- |
- |
|
General human health issues |
No further information available |
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
General  |
No information available |
CLP classification 2013 |
- |
EC Risk Classification  |
- |
EC Safety Classification  |
- |
WHO Classification |
NL |
- |
Not listed |
US EPA Classification (formulation) |
Not applicable |
- |
- |
UN Number |
- |
Waste disposal & packaging  |
- |
TRANSLATIONS
Language |
Name |
English |
2-hydroxyquinoxaline |
French |
- |
German |
- |
Danish |
- |
Italian |
- |
Spanish |
- |
Greek |
- |
Slovenian |
2-hidroksikvinoksalin |
Polish |
2-hydroksychinoksalina |
Swedish |
- |
Hungarian |
- |
Dutch |
- |
Record last updated: Saturday 31 March 2018
Contact: aeru@herts.ac.uk