clorsulon ** MK-401 ** Translations

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GENERAL INFORMATION
for clorsulon

Description: Veterinary medication used to control adult liver flukes in cattle, sheep and other livestock. Also used on domestic pets.

Availability status: -

Introduction & key dates: -

Examples of species treated: Domestic pets, farm livestock particularly cattle

Chemical structure:

Isomerism	-
Chemical formula	C8H8Cl3N3O4S2
Canonical SMILES	C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	QOVTVIYTBRHADL-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
2D structure diagram/image available?	Yes

General status:

Veterinary substance type	Antiparasitic
Substance group	Sulphonamide
Minimum active substance purity	-
Known relevant impurities	-
Substance origin	Synthetic
Mode of action	Inhibits the enzymes phosphoglycerate kinase and phosphoglyceromutase
Molecular targets	-
CAS RN	60200-06-8
EC number	262-100-2
CIPAC number	-
US EPA chemical code	-
PubChem CID	-
ATCvet Code	QP54AA51
Therapeutic Class	Antiparasitic products, insecticides & repellents: Endectocides
Controlled Drug?	No
Regulation 37/2010 MRL Classification	No data
Molecular mass (g mol-1)	380.66
PIN (Preferred Identification Name)	-
IUPAC name	4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
CAS name	4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide
Other status information	-
Relevant Environmental Water Quality Standards	-
Physical state	White to off-white crystalline powder
Related substances & organisms	ivermectin

Formulations:

Property	Product	Manufacturer	Authorisation Route	UK Legal Class
Example products using this active	Animec Super Solution for Cattle Injection	Chanelle Animal Health Ltd	UK National authorisation	Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
	Ivomac Super Solution for Cattle Injection	Merial Animal Health	UK National authorisation	Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
	Virbamec Super Solution for Injection	Virbac Ltd	UK National authorisation (MAPI)	Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Formulation and application details	Usually supplied as a solution for injection.

ENVIRONMENTAL FATE
for clorsulon

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		-	-	-
Solubility - In organic solvents at 20oC (mg l-1)		-	-	-
Melting point (oC)		203	V3	-
Boiling point (oC)		652	V3	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		348	V3	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.23 X 1001	Calculated	-
	Log P	1.09	V3	Low
Bulk density (g ml-1)/Specific gravity		-	-	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 20oC (mPa)		-	-	-
Henry's law constant at 25oC (Pa m3 mol-1)		-	-	-
GUS leaching potential index		-	-	-
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-
Refractive Index		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	-	-	-
	DT50 (lab at 20oC)	-	-	-
	DT50 (field)	-	-	-
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note:	-
Manure DT50 (days)		-	-	-
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	-	-	-
	Note	-
Water-sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

ECOTOXICOLOGY
for clorsulon

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	-	-	-
	CT50 (days)	-		-
Mammals - Acute oral LD50 (mg kg-1)		> 10000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	-	-	-
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		-	-	-
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		-	-	-
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		-	-	-
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		-	-	-
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	-	-	-
	Oral acute 48 hour LD50 (μg bee-1)	-	-	-
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		-	-	-
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for clorsulon

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		> 10000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		-	-	-
Mammals - Inhalation LC50 (mg l-1)		-	-	-
Other Mammal toxicity endpoints		Intraperitoneal LD50 = 808 mg kg-1	A5 Rat	-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.002	A4 Dog, SF=1000	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Elimination route and rate		Rapidly excreted in the faeces of animals	Q3	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
		-		-	-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
		-		-
General human health issues		Possible thyroid toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		No information available
CLP classification 2013		-
EC Risk Classification		-
EC Safety Classification		S26-37, S39-45
WHO Classification		None - not a ppp	-	-
US EPA Classification (formulation)		-	-
UN Number		-
Waste disposal & packaging		-

TRANSLATIONS
for clorsulon

Language	Name
English	clorsulon
French	clorsulone
German	-
Danish	-
Italian	-
Spanish	clorsulon
Greek	-
Slovenian	-
Polish	-
Swedish	-
Hungarian	-
Dutch	-

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Record last updated: Monday 02 April 2018
Contact: aeru@herts.ac.uk