Environmental Fate - Ecotoxicology - Human Health
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GENERAL INFORMATION
for clorsulon
Description:
Veterinary medication used to control adult liver flukes in cattle, sheep and other livestock. Also used on domestic pets.
Availability status:
-
Introduction & key dates:
-
Examples of species treated:
Domestic pets, farm livestock particularly cattle
Chemical structure:
Isomerism |
- |
Chemical formula |
C8H8Cl3N3O4S2 |
Canonical SMILES |
C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl |
Isomeric SMILES |
No data |
International Chemical Identifier key (InChIKey) |
QOVTVIYTBRHADL-UHFFFAOYSA-N |
International Chemical Identifier (InChI) |
InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18) |
2D structure diagram/image available? |
Yes |
General status:
Veterinary substance type |
Antiparasitic |
Substance group |
Sulphonamide |
Minimum active substance purity |
- |
Known relevant impurities |
- |
Substance origin |
Synthetic |
Mode of action |
Inhibits the enzymes phosphoglycerate kinase and phosphoglyceromutase |
Molecular targets |
- |
CAS RN |
60200-06-8 |
EC number |
262-100-2 |
CIPAC number |
- |
US EPA chemical code |
- |
PubChem CID |
- |
ATCvet Code |
QP54AA51 |
Therapeutic Class |
Antiparasitic products, insecticides & repellents: Endectocides |
Controlled Drug? |
No |
Regulation 37/2010 MRL Classification |
No data |
Molecular mass (g mol-1) |
380.66 |
PIN (Preferred Identification Name) |
- |
IUPAC name |
4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide |
CAS name |
4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide |
Other status information |
- |
Relevant Environmental Water Quality Standards |
- |
Physical state |
White to off-white crystalline powder |
Related substances & organisms |
|
Formulations:
Property  |
Product |
Manufacturer |
Authorisation Route |
UK Legal Class |
Example products using this active |
Animec Super Solution for Cattle Injection |
Chanelle Animal Health Ltd |
UK National authorisation |
Prescription only medicine to be authorised by suitably qualified person (POM-VPS) |
Ivomac Super Solution for Cattle Injection |
Merial Animal Health |
UK National authorisation |
Prescription only medicine to be authorised by suitably qualified person (POM-VPS) |
Virbamec Super Solution for Injection |
Virbac Ltd |
UK National authorisation (MAPI) |
Prescription only medicine to be authorised by suitably qualified person (POM-VPS) |
Formulation and application details |
Usually supplied as a solution for injection. |
ENVIRONMENTAL FATE
for clorsulon
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Solubility - In water at 20oC (mg l-1) |
- |
- |
- |
Solubility - In organic solvents at 20oC (mg l-1) |
- |
- |
- |
Melting point (oC) |
203 |
V3 |
- |
Boiling point (oC) |
652 |
V3 |
- |
Degradation point (oC) |
- |
- |
- |
Flashpoint (oC) |
348 |
V3 |
- |
Octanol-water partition coefficient at pH 7, 20oC |
P |
1.23 X 1001 |
Calculated |
- |
Log P |
1.09 |
V3 |
Low |
Bulk density (g ml-1)/Specific gravity |
- |
- |
- |
Dissociation constant (pKa) at 25oC |
- |
- |
- |
Note: |
Vapour pressure at 20oC (mPa) |
- |
- |
- |
Henry's law constant at 25oC (Pa m3 mol-1) |
- |
- |
- |
GUS leaching potential index  |
- |
- |
- |
Maximum UV-vis absorption L mol-1 cm-1 |
- |
- |
- |
Surface tension (mN m-1) |
- |
- |
- |
Refractive Index |
- |
- |
- |
Degradation:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Soil degradation (days) (aerobic) |
DT50 (typical) |
- |
- |
- |
DT50 (lab at 20oC) |
- |
- |
- |
DT50 (field) |
- |
- |
- |
DT90 (lab at 20oC) |
- |
- |
- |
DT90 (field) |
- |
- |
- |
Note: |
- |
Manure DT50 (days) |
- |
- |
- |
Aqueous photolysis DT50 (days) at pH 7 |
Value |
- |
- |
- |
Note |
- |
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 |
Value |
- |
- |
- |
Note |
- |
Water-sediment DT50 (days) |
- |
- |
- |
Water phase only DT50 (days) |
- |
- |
- |
Soil adsorption and mobility:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Linear
| Kd |
- |
- |
- |
Koc |
- |
Notes and range |
- |
Freundlich
| Kf |
- |
- |
- |
Kfoc |
- |
1/n |
- |
Notes and range |
- |
pH sensitivity |
- |
ECOTOXICOLOGY
for clorsulon
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Bio-concentration factor |
BCF (l kg-1) |
- |
- |
- |
CT50 (days) |
- |
- |
Mammals - Acute oral LD50 (mg kg-1) |
> 10000 |
A5 Rat |
Low |
Mammals - Short term dietary NOEL |
(mg kg-1) |
- |
- |
- |
(ppm diet) |
- |
- |
Birds - Acute LD50 (mg kg-1) |
- |
- |
- |
Birds - Short term dietary (LC50/LD50) |
- |
- |
- |
Fish - Acute 96 hour LC50 (mg l-1) |
- |
- |
- |
Fish - Chronic 21 day NOEC (mg l-1) |
- |
- |
- |
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) |
- |
- |
- |
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) |
- |
- |
- |
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) |
- |
- |
- |
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) |
- |
- |
- |
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) |
- |
- |
- |
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) |
- |
- |
- |
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) |
- |
- |
- |
Non-target plants |
- |
- |
- |
- |
- |
- |
Algae - Acute 72 hour EC50, growth (mg l-1) |
- |
- |
- |
Algae - Chronic 96 hour NOEC, growth (mg l-1) |
- |
- |
- |
Honeybees |
Contact acute 48 hour LD50 (μg bee-1) |
- |
- |
- |
Oral acute 48 hour LD50 (μg bee-1) |
- |
- |
- |
Unknown mode acute 48 hour LD50 (μg bee-1) |
- |
- |
- |
Earthworms - Acute 14 day LC50 (mg kg-1) |
- |
- |
- |
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) |
- |
- |
- |
Other soil macro-organisms - e.g. Collembola |
LR50 / EC50 / NOEC / % Effect |
- |
- |
- |
Other arthropod (1) |
LR50 g ha-1 |
- |
- |
- |
% Effect |
- |
- |
- |
Other arthropod (2) |
LR50 g ha-1 |
- |
- |
- |
% Effect |
- |
- |
- |
Soil micro-organisms |
- |
- |
- |
Mesocosm study data |
NOEAEC mg l-1 |
- |
- |
- |
NOEAEC mg l-1 |
- |
- |
- |
HUMAN HEALTH AND PROTECTION
for clorsulon
General:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
Threshold of Toxicological Concern (Cramer Class)  |
High (class III) |
- |
- |
Mammals - Acute oral LD50 (mg kg-1) |
> 10000 |
A5 Rat |
Low |
Mammals - Dermal LD50 (mg kg-1 body weight) |
- |
- |
- |
Mammals - Inhalation LC50 (mg l-1) |
- |
- |
- |
Other Mammal toxicity endpoints |
Intraperitoneal LD50 = 808 mg kg-1 |
A5 Rat |
- |
ADI - Acceptable Daily Intake (mg kg-1bw day-1) |
0.002 |
A4 Dog, SF=1000 |
- |
ARfD - Acute Reference Dose (mg kg-1bw day-1) |
- |
- |
- |
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) |
- |
- |
- |
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) |
- |
- |
- |
Dermal penetration studies (%) |
- |
- |
- |
Dangerous Substances Directive 76/464 |
- |
- |
- |
Exposure Limits |
- |
- |
- |
Exposure Routes |
Public |
- |
Occupational |
- |
Elimination route and rate |
Rapidly excreted in the faeces of animals |
Q3 |
- |
Health issues:
Carcinogen |
Mutagen |
Endocrine disrupter |
Reproduction / development effects |
Cholinesterase inhibitor |
Neurotoxicant |

|

|
- |

|
- |
- |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
Eye irritant |
Phototoxicant |
|

|

|
- |

|
- |
|
General human health issues |
Possible thyroid toxicant |
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
Property  |
Value |
Source/Quality Score/Other Information  |
Interpretation  |
General  |
No information available |
CLP classification 2013 |
- |
EC Risk Classification  |
- |
EC Safety Classification  |
S26-37, S39-45 |
WHO Classification |
None - not a ppp |
- |
- |
US EPA Classification (formulation) |
- |
- |
|
UN Number |
- |
Waste disposal & packaging  |
- |
TRANSLATIONS
for clorsulon
Language |
Name |
English |
clorsulon |
French |
clorsulone |
German |
- |
Danish |
- |
Italian |
- |
Spanish |
clorsulon |
Greek |
- |
Slovenian |
- |
Polish |
- |
Swedish |
- |
Hungarian |
- |
Dutch |
- |
Record last updated: Monday 02 April 2018
Contact: aeru@herts.ac.uk