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clorsulon
** MK-401 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for clorsulon

Description: Veterinary medication used to control adult liver flukes in cattle, sheep and other livestock. Also used on domestic pets.

Availability status: -

Introduction & key dates: -

Examples of species treated: Domestic pets, farm livestock particularly cattle

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C8H8Cl3N3O4S2
Canonical SMILES C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) QOVTVIYTBRHADL-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Veterinary substance type Antiparasitic
Substance group Sulphonamide
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Inhibits the enzymes phosphoglycerate kinase and phosphoglyceromutase
Molecular targets -
CAS RN 60200-06-8
EC number 262-100-2
CIPAC number -
US EPA chemical code -
PubChem CID -
ATCvet Code QP54AA51
Therapeutic Class Antiparasitic products, insecticides & repellents: Endectocides
Controlled Drug? No
Regulation 37/2010 MRL Classification No data
Molecular mass (g mol-1) 380.66
PIN (Preferred Identification Name) -
IUPAC name 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
CAS name 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide
Other status information -
Relevant Environmental Water Quality Standards -
Physical state White to off-white crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Product Manufacturer Authorisation Route UK Legal Class
Example products using this active Animec Super Solution for Cattle Injection Chanelle Animal Health Ltd UK National authorisation Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Ivomac Super Solution for Cattle Injection Merial Animal Health UK National authorisation Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Virbamec Super Solution for Injection Virbac Ltd UK National authorisation (MAPI) Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Formulation and application details Usually supplied as a solution for injection.


ENVIRONMENTAL FATE

for clorsulon

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) - - -
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 203 V3 -
Boiling point (oC) 652 V3 -
Degradation point (oC) - - -
Flashpoint (oC) 348 V3 -
Octanol-water partition coefficient at pH 7, 20oC P 1.23 X 1001 Calculated -
Log P 1.09 V3 Low
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) - - -
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -
Refractive Index - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note: -
Manure DT50 (days) - - -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for clorsulon

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 10000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) - - -
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) - - -
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) - - -
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for clorsulon

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 10000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) - - -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 808 mg kg-1 A5 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.002 A4 Dog, SF=1000 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Elimination route and rate Rapidly excreted in the faeces of animals Q3 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible thyroid toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases -
EC Safety Classification Click here to view information omn the EU safety phrases S26-37, S39-45
WHO Classification None - not a ppp - -
US EPA Classification (formulation) - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for clorsulon

Language Name
English clorsulon
French clorsulone
German -
Danish -
Italian -
Spanish clorsulon
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Monday 02 April 2018
Contact: aeru@herts.ac.uk