Doramectin |
![]() Last updated: 31/08/2023 |
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(Also known as: UK-67994) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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![]() Significant data are missing |
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Used for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle and other animals | |
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1975 | |
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Cattle, Sheep, Pigs |
Chemical structure |
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Doramectin a chiral molecule | |
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C₅₀H₇₄O₁₄ | |
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CC1C=CC=C2COC3C2(C(C=C(C3O)C)C(=O)OC4CC(CC=C(C1OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)O)OC)OC)C)OC7(C4)C=CC(C(O7)C8CCCCC8)C)O | |
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C[C@H]1C=C[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H](C([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)O[C@@H]1C8CCCCC8 | |
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QLFZZSKTJWDQOS-YDBLARSUSA-N | |
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InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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Doramectin monohydrate | Variant | ![]() |
General status |
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Antiparasitic, Endoparasitic, Acaricide, Insecticide, Anthelmintic | |
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Avermectin | |
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Synthetic | |
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Broad spectrum, induces rapid, non-spastic paralysis in nematodes and arthropods. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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[Glycine receptor subunit alpha-3, agonist], [Gamma-aminobutyric-acid (GABA) receptor subunit beta-3, agonist] | |
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117704-25-3 | |
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9832750 | |
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QP54AA03 | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species) | |
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899.11 | |
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1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one | |
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25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a | |
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- | |
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UK Environment Agency non-statutory standard for the protection of aquatic life in freshwater and saltwater: 0.001 µg l⁻¹ as annual average, 0.01 µg l⁻¹ as max acceptable conc. | |
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Off-white crystalline solid | |
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Formulations |
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Dectomax 10 mg/ml Solution for Injection for Cattle and Sheep | Elanco Animal Health | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Dectomax 10 mg/ml Solution for Injection for Pigs | Elanco Animal Health | EC Mutually recognised procedure | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Dectomax Pour-On Solution for Cattle 5 mg/ml | Elanco Animal Health | EC Mutually recognised procedure | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually supplied as solution for injection or as a pour-on for topical application |
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0.025 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low | ||||||||
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118 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.95 X 1007 | Calculated | - | |||||||
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7.47 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.25 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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12.42 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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70 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | |||||||
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Literature DT₅₀ range 61-79 days | ||||||||||
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22 | R4 R = Peer reviewed scientific publications Sheep faeces4 = Verified data |
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-mobile | |||||||
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35900 | ||||||||||
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Literature Koc range 7520 (silty loam) - 86900 (silty clay loam) mL g⁻¹; Koc = 34100 mL g⁻¹ cattle faeces | ||||||||||
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Fate indices |
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-1.02 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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3'-O-desmethyl doramectin | - | Cattle (Liver, Faeces) | - | - | |||||
24-hydroxymethyl doramectin | - | Cattle (Liver, Faeces) | - | - | |||||
24-hydroxymethyl-3'-O-desmethyl doramectin | - | Cattle (Liver, Faeces) | - | - |
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Terrestrial ecotoxicology |
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> 1000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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> 2000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Colinus virginianus3 = Unverified data of known source |
Low | ||||||||
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> 1000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Eisenia foetida3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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0.0051 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
High | ||||||||
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0.0001 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.000025 | R3 R = Peer reviewed scientific publications Daphnia magna 48 hour NOEC3 = Unverified data of known source |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Most of the administered does is eliminated in the faeces, only around 1% is lost in the urine | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Health issues |
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May cause mild tachycardia, hypotension, fever, and hypothermia |
Handling issues |
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Emits toxic fumes under fire conditions IMDG Transport Hazard Class 6.1 |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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doramectin | ||
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doramectina | ||
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doramectina | ||
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Record last updated: | 31/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |