Emodepside
Last updated: 08/04/2021
(Also known as: BAY 44-4400; BAY 44-8; PF 1022-221)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
An anthelmintic drug that is effective against a number of gastrointestinal nematodes including ascarids and hookworms
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1990, research started
Cats, Dogs
Isomeric
C₆₀H₉₀N₆O₁₄
CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C
C[C@@H]1C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C
ZMQMTKVVAMWKNY-YSXLEBCMSA-N
InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1
Yes
Antiparasitic, Anthelmintic, Nematicide
Cyclic octadepsipeptides
>950g kg⁻¹
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Semi-synthetic
Acts by stimulation of the presynaptic latrophilin receptor causing paralysis and death of the parasite
[Latrophilin receptor, binder]
155030-63-0
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QP52AA51
Antiparasitic products, insecticides & repellents: Anthelmintics
No
No data
1119.39
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cyclo[(R)-2-hydroxypropanoyl-(N-méthyl-L-leucyl)-[(R)-3-[4-(morpholin-4-yl)phényl]-2-hydroxypropanoyl]-(N-méthyl-L-leucyl)-(R)-2-hydroxypropanoyl-(N-méthyl-L-leucyl)-[(R)-3-[4-(morpholin-4-yl)phényl]-2-hydroxypropanoyl]-(N-méthyl-L-leucyl)]
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White to pale yellow powder
Profender modified-release tablets for small dogs
Bayer Animal Health GmbH
EU centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Profender modified-release tablets for large dogs
Bayer Animal Health GmbH
EU centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Profender spot-on solution for small cats
Bayer Animal Health GmbH
EU centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Profender spot-on solution for large cats
Bayer Animal Health GmbH
EU centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including tablets and spot-on solutions
5.2
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Low
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7.94 X 1004
Calculated
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4.9
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
High
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
High (class III)
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Faecal excretion predominates
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
No further information available
No information available
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Not listed (Not listed)
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emodepside
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242