Erythromycin
Last updated: 16/03/2023
(Also known as: EES; abomacetin; abomacetin; erythromycin A)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An antibiotic produced by Streptomyces erythreus and used to treat a range of bacterial infections mainly in chickens
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1953, patented; 1968, first reviewed
Poultry, cattle, sheep, pigs
Isomeric
C₃₇H₆₇NO₁₃
CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
ULGZDMOVFRHVEP-UMCXFAKASA-N
InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19+,20+,21+,22-,23+,24-,25-,26+,28+,29+,30-,31+,32-,34-,35-,36-,37-/m1/s1
Yes
Antibiotic, Antibacterial, Antimicrobial, Medicinal drug
Macrolide
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FAO: N-demethyl-erythromycin A; anhydroerythromycin A; erythromycin A enol ether; pseudoerythromycin A enol ether, erythromycin E, erythromycin F
Natural
Inhibits protein synthesis which is the basis of this antimicrobial action
[3S rRNA, antagonist], [50S ribosomal protein L22, antagonist], [50S ribosomal protein L4, antagonist]
114-07-8
204-040-1
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QJ51FA01
Antiinfectants for systemic use: Antibacterials for intramammary use
No
Allowed substance (Table 1: All food producing species)
733.93
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(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
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White to slightly yellow crystalline solid, slightly hygroscopic
Erythrocin 16.5% w/w soluble powder for oral solution
Ceva Animal Health Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Erythrocin Proportioner
Ceva Animal Health Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in enteric-coated tablets, slow-release capsules, oral suspensions, ophthalmic solutions, ointments, gels, and injections
1.44
Low
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135
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
resolidifies MP(2) = 190
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1.15 X 1003
Calculated
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3.06
High
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8.88
R4 R = Peer reviewed scientific publications 4 = Verified data
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@ 25DegC
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pH 6.3: 280nm
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11
Temp and OM dependent data for sandy loam+cattle manure 20°C
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Stable
Stable
Not expected to undergo hydrolysis
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Soil adsorption and mobility
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Slightly mobile
570
Estimated
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Known soil and groundwater metabolites
None
des-N-methyl-erythromycin Note: Major metabolite; Pharmacologically active
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Humans (Liver)
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Cytochrome P450 3A4
Terrestrial ecotoxicology
> 4600
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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349
Morone saxatilis
Low
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30.5
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Moderate
0.25
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Moderate
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> 1000
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Lemna gibba as LOEC
Low
0.02
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Pseudokirchneriella subcapitata
Moderate
0.01
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 4600
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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Subcutaneous LD₅₀ = 427 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 426 mg kg⁻¹
Mouse
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Largely (~95%) metabolised by the liver and excreted in the bile and to lesser extent the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause diarrhoea, nausea, abdominal pain, and vomiting Reported cases of hearing impairment Kidney, liver and lungs toxicant
No information available
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Not listed (Not listed)
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erythromycin
erythromycine
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eritromicina
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Record last updated:
16/03/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242