Tulathromycin A |
![]() Last updated: 31/08/2023 |
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(Not known by any other names) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A veterinary drug used to treat bovine respiratory disease (BRD) in cattle and swine respiratory disease in pigs | |
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Cattle, Pigs |
Chemical structure |
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Isomeric mixture | |
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C₄₁H₇₉N₃O₁₂ | |
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CCCNCC1(C(OC(CC1(C)OC)OC2C(C(C(CC(CNC(C(C(C(OC(=O)C2C)CC)(C)O)O)C)C)(C)O)OC3C(C(CC(O3)C)N(C)C)O)C)C)O | |
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CCCNC[C@@]1([C@@H](O[C@H](C[C@@]1(C)OC)O[C@H]2[C@@H]([C@H]([C@](C[C@H](CN[C@@H]([C@H]([C@]([C@H](OC(=O)[C@@H]2C)CC)(C)O)O)C)C)(C)O)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)C)C)O | |
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GUARTUJKFNAVIK-KMKQSXFFSA-N | |
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InChI=1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)55-33-25(5)35(56-37-32(45)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)34(46)40(11,49)30(16-2)54-36(47)26(33)6/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3/t23-,24-,25+,26-,27-,28+,29+,30-,31+,32-,33+,34-,35-,37+,38-,39-,40-,41+/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Macrolide | |
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>940 g/Kg | |
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Semi-synthetic | |
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Inhibits protein synthesis by selectively binding to 23S ribosomal RNA | |
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[23S rRNA, antagonist] | |
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217500-96-4 | |
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9832301 | |
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QJ01FA94 | |
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Antiinfectives for systemic use: Antibacterials for systemic use | |
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No | |
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Allowed susbtance (Table 1: Bovince, Porcine) | |
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806.23 | |
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(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one | |
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White to off-white coloured solid | |
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Formulations |
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Draxxin Solution for injection for Cattle and Pigs | Pfizer Ltd | EU Centralised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Rexxolide | Dechra Ltd | - | - | |||||||
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Usually supplied as solution for injection |
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190 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.17 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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8.49 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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> 20 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Cyprinodon variegatus 3 = Unverified data of known source |
Moderate | ||||||||
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> 20 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna 1 hour3 = Unverified data of known source |
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General |
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> 2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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2000 | E3 E = Manufacturers safety data sheets Rabbit3 = Unverified data of known source |
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0.05 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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Excreted with some metabolism but mainly as the unchanged drug in the faeces and urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible liver toxicant May cause diarrhoea and other gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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tulathromycin A | ||
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Record last updated: | 31/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |