Nalidixic acid
Last updated: 17/08/2023
(Also known as: naladixic acid; nalidixate)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Synthetic quinolone antibiotic used in treating urinary tract infections such as those caused by Escherichia coli, Proteus, Shigella and Enterobacter
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circa 1965
Pigs, Poultry
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C₁₂H₁₂N₂O₃
CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)O
No data
MHWLWQUZZRMNGJ-UHFFFAOYSA-N
InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
nalidixic acid
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Antibiotic, Antibacterial, Medicinal drug
Naphthyridone
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Synthetic
Inhibits bacterial DNA gyrase
[DNA]
389-08-2
206-864-7
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QJ01MB02
Antiinfectants for systemic use: Antibacterials for systemic use
No
No data
232.24
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1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid
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Evidence of use in third world countries
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White to beige crystalline solid
None identified
None identified
No UK authorisation for use with animals
Not applicable
Usually formulated for oral administration
100
Moderate
35000
Chloroform
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1600
Toluene
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1300
Methanol
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600
Ethanol
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230
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1.51 X 1001
Calculated
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1.18
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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6.21
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333nm = 1138
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
hydroxynalidixic acid Note: Pharmacologically active
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Terrestrial ecotoxicology
1160
R4 R = Peer reviewed scientific publications 4 = Verified data
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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1160
R4 R = Peer reviewed scientific publications 4 = Verified data
Rat
Moderate
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Subcutaneous LD₅₀ = 1584 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 1160 mg kg⁻¹
Rat
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Rapidly absorbed from the gastrointestinal tract, partially metabolized in the liver and rapidly excreted predominately in the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause gastrointestinal problems May cause muscle pain, confusion, depression, weakness, headache and dizziness
When heated to decomposition it emits toxic fumes of nitroxides
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Not listed (Not listed)
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nalidixic acid
acide nalidixique
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acide nalidixico
acido nalidixico
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Record last updated:
17/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242