Cinoxacin
Last updated: 08/04/2021
(Also known as: compound 64716)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
An oboselete antimicrobial drug used, albeit rarely in animals, to treat various infections caused by Gram-negative aerobes
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1972, patent
Dogs, Cats
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C₁₂H₁₀N₂O₅
CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3
No data
VDUWPHTZYNWKRN-UHFFFAOYSA-N
InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
cinoxacin
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Antimicrobial, Antibiotic, Antibacterial, Medicinal drug
Quinolone
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Synthetic
Inhibits DNA gyrase, thereby inhibiting cell division
[DNA gyrase subunit A, antagonist], [DNA, intercalation]
28657-80-9
249-133-8
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Not listed
None
Not applicable
No data
262.22
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1-ethyl-1,4-dihydro- 4-oxo[1,3] dioxolo[4,5-g]cinnoline-3-carboxylic acid
1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid
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Pale beige coloured crystalline solid
None identified
None identified
No UK authorisation for use with animals
Not applicable
Now largely obsolete but was administered orally via tablets
961
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
High
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261
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3.89 X 1001
Calculated
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1.59
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
3610
Rat
Low
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73
Anguilla japonica
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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3610
Rat
Low
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Subcutaneous LD₅₀ = 1380 mg kg⁻¹
L4 L = Pesticide manuals and hard copy reference books / other sources 4 = Verified data
Rat
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Intravenous LD₅₀ = 860 mg kg⁻¹
R4 R = Peer reviewed scientific publications 4 = Verified data
Rat
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Rapidly absorbed, some metabolism and excreted in the urine ~60% unchanged
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Gastrointestinal and renal system toxicant causing anorexia, nausea, vomiting, epigastric distress and diarrhoea May cause hyposensitivity
Considered non-hazardous for air and sea shipping
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Not listed (Not listed)
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cinoxacin
cinoxacine
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cinoxacino
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242