Enoxacin
Last updated: 24/06/2022
(Also known as: AT-2266)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A broad-spectrum antibiotic drug particularly effective against Gram-negative organisms and staphylococci
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C₁₅H₁₇FN₄O₃
CCN1C=C(C(=O)C2=CC(=C(N=C21)N3CCNCC3)F)C(=O)O
No data
IDYZIJYBMGIQMJ-UHFFFAOYSA-N
InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
enoxacin carboxylate
Variant
exoxacin hydrate
Variant
Antibiotic, Antibacterial, Medicinal drug
Fluoroquinolone
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Nucleic acid synthesis inhibitor - inhibits DNA gyrase
[DNA gyrase subunit A, antagonist], [DNA topoisomerase 4 subunit A, antagonist], [DNA topoisomerase 2-alpha, antagonist],
74011-58-8
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QJ01MA04
Antiinfectants for systemic use: Antibacterials for systemic use
No
No data
320.32
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1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
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Yellow to white crystalline solid
None identified
None identified
No UK authorisation for use with animals
Not applicable
Usually administered orally
3430
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
High
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222
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5.01 X 10-03
Calculated
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-2.3
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low
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1.388
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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6.04
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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6.37 X 10-08
Low volatility
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
3-oxoenoxacin Note: A somewhat pharmacologically active metabolite, less so than parent
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Human
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Terrestrial ecotoxicology
> 5000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 5000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 236 mg kg⁻¹
Rat
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Heptic. 44 to 62% of an administered dose is excreted as unchanged drug in urine.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause gastrointestinal problems
May present a fire and explosion hazard Avoid generation of dusts
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Not listed (Not listed)
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enoxacin
enoxacine
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enoxacino
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Record last updated:
24/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242