Terpinen-4-ol |
![]() Last updated: 12/01/2021 |
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(Also known as: Tea tree oil extract; Oil of Melaleuca; TTO; 4-carvomenthenol ; 4-terpinenol) |
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A major component (30-48%) of Tea tree oil which is used to control various fungal pathogens on a wide range of crops | |
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Current | |
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1920s, Tea tree oil first reported | |
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UK regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved (as Tea tree oil) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Poland/Bulgaria | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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31/08/2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Chemical structure |
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C₁₀H₁₈O | |
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CC1=CCC(CC1)(C(C)C)O | |
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No data | |
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WRYLYDPHFGVWKC-UHFFFAOYSA-N | |
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InChI=1S/C10H18O/c1-8(2)10(11)6-4-9(3)5-7-10/h4,8,11H,5-7H2,1-3H3 | |
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Yes |
General status |
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Fungicide, Microbiocide, Other substance | |
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Animal feed additive | |
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Plant derived | |
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300 g/Kg | |
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Natural | |
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Tea tree oil appears to disrupt the permeability barrier of microbial cell membrane structures, causing loss of chemiosmotic control. | |
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Originates as a natural remedy used by Australia indiginous people to treat various ailments | |
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Tea tree oil is harvested by steam extraction from the leaves and branches of the plant Melaleuca alternifolia | |
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Crop protection | |
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Various fungal pathogens including powdery mildew on fruit & vegetables and early blight on potatoes | |
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Various crops including potatoes, carrots, tomatoes, cucumbers, fruit and ornamentals | |
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Tea tree oil is suitable for use in organic farming and for IPM where approved for use in that country | |
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562-74-3 | |
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209-235-5 | |
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154.25 | |
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1-methyl-4-isopropyl-1-cyclohexen-4-ol | |
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terpinen-4-ol | |
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FLAVIS No. 02.072 | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Clear liquid | |
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Formulations |
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Timorex | BioMor Latvija | ||||
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Tea tree oil is usually supplied as an emulsifable concentrate that is diluted and used as a foliar spray |
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1767 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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14.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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211 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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79 | E3 E = Manufacturers safety data sheets (closed cup)3 = Unverified data of known source |
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2.14 X 1003 | Calculated | - | |||||||
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3.33 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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0.933 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Not applicable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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No dissociation | |||||||||||
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53200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Highly volatile | ||||||||
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4.64 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately volatile | ||||||||
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Degradation |
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Soil adsorption and mobility |
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- | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
Mobile | |||||||
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61.2 | ||||||||||
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EU dossier - estimated | ||||||||||
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1300 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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> 1000 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) predicted data3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1300 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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2500 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rabbit3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 250 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 750 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Mouse3 = Unverified data of known source |
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Health issues |
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Harmful is swallowed |
Handling issues |
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Not explosive or oxidising | |||
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Health: H302, H315, H317, H319, H336 | |||
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Xn - Harmful: R22 Xi - Irritant: R36/37/38 |
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NL (Not listed) | |||
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terpinen-4-ol | ||
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Record last updated: | 12/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |