Emamectin B1a |
![]() Last updated: 09/09/2025 |
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(Also known as: abamectin-aminomethyl B1a) |
Hazard alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate | Ecotoxicity | Human health |
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A naturally occuring soil Actinomycete effective against various insect pests | |
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Caterpillars; Mites; Thrips; Leaf miners | |
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Fruit trees; Leafy crops including lettuce, brassicas | |
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GB regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Netherlands | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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15/11/2026 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Chemical structure |
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Emamectin B1a exhibits complex stereoisomerism due to its large, polycyclic structure and numerous chiral centres. The molecule contains multiple asymmetric carbon atoms, each capable of adopting either R or S configuration, which gives rise to a specific three-dimensional arrangement essential for its biological activity. Emamectin B1a also includes conjugated double bonds, which introduce geometric (E/Z) isomerism. The biologically active form used in veterinary medicine is a single stereoisomer, carefully controlled during synthesis to maintain efficacy and safety. | |
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C₄₉H₇₅NO₁₃ | |
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CCC(C)C1C(C=CC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)NC)OC)OC)C)C | |
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CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@@H]([C@@H](O7)C)NC)OC)OC)\C)C | |
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CXEGAUYXQAKHKJ-COFQVFHOSA-N | |
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InChI=1S/C49H75NO13/c1-12-26(2)44-29(5)18-19-48(63-44)24-35-21-34(62-48)17-16-28(4)43(27(3)14-13-15-33-25-56-46-42(51)30(6)20-36(47(52)59-35)49(33,46)53)60-40-23-38(55-11)45(32(8)58-40)61-39-22-37(54-10)41(50-9)31(7)57-39/h13-16,18-20,26-27,29,31-32,34-46,50-51,53H,12,17,21-25H2,1-11H3/b14-13+,28-16+,33-15+/t26-,27-,29-,31-,32-,34+,35-,36-,37-,38-,39-,40-,41+,42+,43-,44+,45-,46+,48+,49+/m0/s1 | |
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Yes |
General status |
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Fungicide; Other substance; Veterinary substance | |
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Bactericide | |
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Micro-organism derived substance | |
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Non-systemic, acts by causing insect paralysis. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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Produced by the fermentation of the soil actinomycete Streptomyces avermitilis | |
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Crop protection | |
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Caterpillars; Mites; Thrips; Leaf miners | |
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Fruit trees; Leafy crops including lettuce, brassicas | |
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121124-29-6 | |
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791 | |
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886.1 | |
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(10E,14E,16E)-(1R,4S,5S,6S,6R,8R,12S,13S,20R,21R,24S)-6-[(S)-secbutyl]-21,24-dihydroxy-5,11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.1.0]pentacosa-10,14,16,22-tetraene)-6-spiro-2Œ-(5,6-dihydro-2H-pyran)-12-yl 2,6-dideoxy-3-O-methyl-4-O-(2,4,6-trideoxy-3-O-methyl-4-methylamino-α-L-lyxo-hexapyranosyl)-)α-L-arabino-hexapyranoside | |
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(4R)-5-O-demethyl-4-deoxy-4-(methylamino)avermectin A1a | |
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Not applicable | |
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Not applicable | |
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6 | |
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BM02 | |
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White or faintly yellow powder | |
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Commercial |
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Current | |||
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1997, introduced Israel and Japan; 1999, introduced USA | |||
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Usually formulated as the benzoate. It is usually supplied as an emulsifiable concentrate and soluble granules for crops & as a trunk injection for trees. Often used as medicated pre-mix feed for animal health. | |||
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Emamectin B1a is produced commercially through a multi-step chemical synthesis process. The process begins with the fermentation of a specific strain of the bacterium Streptomyces avermitilis, which produces avermectin B1a as a secondary metabolite. The avermectin B1a is then chemically modified to produce emamectin B1a. This involves several steps, including oxidation and amination reactions. The resulting emamectin B1a is purified to remove any impurities and by-products. This is typically done using high-performance liquid chromatography (HPLC) or other purification techniques. | |||
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There is no publicly available LCA data on GHG emissions specifically for the manufacture of emamectin B1a. However, based on similar fermentation-derived insecticides and estimated GHG emissions: are in the region of 10–25 kg CO₂e per kg of emamectin B1a |
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21 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Moderate | ||||||||
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1.00 X 1005 | Calculated | - | |||||||
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5.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Known soil metabolites |
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Known groundwater metabolites |
None
Other known metabolites |
None
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Terrestrial ecotoxicology |
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89.0 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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89.0 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Partially metabolised and excreted mainly in the faeces | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause climical tremors |
Handling issues |
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Not explosive or oxidising Not explected to auto-ignite, Not highly flammable |
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Health: H301, H311, H331, H372, H318, H319 Environment: H400 |
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Not listed (Not listed) | |||
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emamectin B1a | ||
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Record last updated: | 09/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |