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PhD Oportunity with Syngenta & the University of Hertfordshire

DDT (Ref: OMS 16)
** clofenotane ** dichlorodiphenyltrichloroethane ** dicofane ** chlorophenothane ** NCI C00464 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

DDT is a banned organochlorine insecticide. It has a low aqueous solubility, is relatively volatile and has a low potential to leach to groundwater. It is highly persistent in soil and non-mobile. It is moderately toxic by the oral route in humans and other mammals but is a carcinogen and endocrine disrupter. It shows a high to moderate level of toxicity to most animals and insects although it is relatively non-toxic to birds

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for DDT

Description: An obsolete insecticide that was used to control insect vectors of disease, especially malaria

Example pests controlled: Mosquitoes; Houseflies; Body lice; Colarado beetles; Gypsy moths

Example applications: Agricultural crops; Domestic houses; Offices, commercial and industrial situations; Non-cropped sites including roads, rights-of-way; parkland

Efficacy & activity: -

Availability status: Obsolete

Introduction & key dates: 1944

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Organochlorine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Non-systemic stomach and contact action. Sodium channel modulator.
CAS RN 50-29-3
EC number 200-024-3
CIPAC number 3
US EPA chemical code 029201
Chiral molecule Chiral, a specific isomer or a derivative of a chiral molecule
Chemical formula C14H9Cl5
SMILES Clc1ccc(cc1)C(c2ccc(Cl)cc2)C(Cl)(Cl)Cl
International Chemical Identifier key (InChIKey) YVGGHNCTFXOJCH-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H
Structure diagram/image available? Yes
Molecular mass (g mol-1) 354.49
PIN (Preferred Identification Name) 1,1'-(2,2,2-trichloroethane-1,1-diyl)bis(4-chlorobenzene)
IUPAC name 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
CAS name 1,1'-(2,2,2-trichloroethylidene)bis(4-chlorobenzene)
Other status information Chemical subject to PIC regulations; POP - regulated by Stockholm Convention; LRTAP Annex I; PAN Dirty Dozen; OSPAR soc; Severe Marine Pollutant; Rotterdam Convention (Class II)
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 3
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Wide variety of insects are resistant
Aedes aegypti
Aedes vittatus
Amblyseius fallacis
Apis mellifera
many varieties of mosquito
Physical state White crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • King Tech
  • Hindustan Insecticides Ltd.
Example products using this active
  • Hildit
  • Heliotox
  • Didigam
  • Dinocide
  • Digmar
  • Genitox
  • Pentachlorin
  • Rukseam
UK LERAP status No UK approval for use or outside scope
Formulation and application details DDT was available in many different formats including aerosols, dustable powders, emulsifiable concentrates, granules and wettable powders.


ENVIRONMENTAL FATE

for DDT

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.006 Q3 Low
Solubility - In organic solvents at 20oC (mg l-1) 1000000 L3 - Cyclohexanone -
850000 L3 - Dichloromethane -
770000 L3 - Benzene -
600000 L3 - Xylene -
Melting point (oC) 109 Q3 -
Boiling point (oC) 185 L2 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 8.13 X 1006 Calculated -
Log P 6.91 V3 High
Bulk density (g ml-1)/Specific gravity 0.99 Q3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 0.025 G4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.43 X 10-01 V3 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -3.89 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 6200 L3 Very persistent
DT50 (lab at 20oC) 2000 A3 Very persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data, PIC DGD; DT50; Other sources: DT50 3 months in tropical regions, 4-30 years temperate regions.
Dissipation rate RL50 on plant matrix Value 6.0 R4 -
Note Published literature RL50 range 1.6-10.8 days, 4 field crops, various matrices, n=5
Dissipation rate RL50 on and in plant matrix Value 20.2 R4 -
Note Published literature RL50 range 3.4-44.0 days, 8 field crops, various matrices, n=13
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - G3 Non-mobile
Koc 151000
Notes and range Log Koc given as 5.18
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
DDE (Ref: HSDB 1625) Soil     Not assessed under 91/414
TDE (Ref: ME-1700) Soil     Not assessed under 91/414


ECOTOXICOLOGY

for DDT

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 3173 F3 (Other literature Log BCF values range 1.9-5.5 (R3)) Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 113 A4 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 160 day -
(ppm diet) 1 -
Birds - Acute LD50 (mg kg-1) > 2240 G4 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 2.5 F4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.13 F4 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 0.005 J4 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) > 0.0027 F3 Chironomus riparius, 1 day High
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.54 F4 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 F3 Eisenia foetida, 56 day Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Moderately harmful AB1 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for DDT

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 113 A4 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2510 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 JMPR 2001 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated JMPR 2000 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Highly toxic
Strong links with breast and womb cancer
Endocrine issues - Competitive binding to androgen receptors

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H301, H351, H372
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
T - Toxic: R25, R48/25
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S22, S36/37, S45, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number 2761
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for DDT

Language Name
English DDT
French DDT
German DDT
Danish DDT
Italian DDT
Spanish DDT
Greek DDT
Slovenian DDT
Polish DDT
Swedish DDT
Hungarian DDT
Dutch DDT

Record last updated: Wednesday 29 November 2017
Contact: aeru@herts.ac.uk