Trimethoprim
Last updated: 03/06/2023
(Also known as: TRI; TMP; trimexazole)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A synthetic bacteriostatic antibiotic used as a veterinary medicine to treat a range of conditions
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Circa 1965, discovered; 1973 approved
Cats, Dogs, Horses, Cattle, Pigs, Turkeys, Sheep
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C₁₄H₁₈N₄O₃
COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
No data
IEDVJHCEMCRBQM-UHFFFAOYSA-N
InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
trimethoprim
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Antibiotic, Antibacterial, Medicinal drug
Diaminopyrimidine
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Synthetic
Interferes with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid
[Thymidylate synthase, antagonist], [Dihydrofolate reductase, antagonist]
738-70-5
212-006-2
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QJ51EA01; QJ01EA01
Antiinfectants for systemic use: Antibacterials for intramammary use, Antibacterials for systemic use
No
Allowed substance (Table 1: Equidae, All food producing species)
290.32
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5-(3,4,5- trimethoxybenzyl) pyrimidine-2,4-diamine
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
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White to cream coloured crystalline powder
Norodine 80mg Tablets
Norbook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Norodine 20 Coated Tablets
Norbook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Trimacare 80- Tablets for Dogs
Norbook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Trimedoxine 80 Tablets
Vetoquinol UK
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including tables and solutions for injections
400
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderate
18200
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Chloroform
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25700
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Propylene glycol
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30
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Ether
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20
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Benzene
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201
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8.13 X 1000
Calculated
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0.91
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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7.12
R4 R = Peer reviewed scientific publications 4 = Verified data
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Weak base
1.31 X 10-03
R4 R = Peer reviewed scientific publications 4 = Verified data
Low volatility
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110
R4 R = Peer reviewed scientific publications 4 = Verified data
Persistent
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31.5
R4 R = Peer reviewed scientific publications 4 = Verified data
Sewage sludge DT59 range 22-41 days
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Soil adsorption and mobility
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R4 R = Peer reviewed scientific publications 4 = Verified data
Slightly mobile
2835
General literature states Koc range 1680-3990 mL g⁻¹
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1.12
Calculated
Low leachability
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Known soil and groundwater metabolites
None
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1-N-oxide metabolite
Animals
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3-N-oxide metabolite
Animals
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4-hydroxy metabolite
Animals
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3-hydroxy metabolite
Animals
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Terrestrial ecotoxicology
4850
Mouse
Low
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> 100
R4 R = Peer reviewed scientific publications 4 = Verified data
Oryzias latipes
Low
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123
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Daphnia magna
Low
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> 1.0
R4 R = Peer reviewed scientific publications 4 = Verified data
lemna gibba LOEC 7 day
Moderate
80.3
Selenastrum capricornutum
Low
25.5
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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4850
Mouse
Low
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Intraperitoneal LD₅₀ = 500 mg kg⁻¹
Rat
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Subcutaneous LD₅₀ > 5000 mg kg⁻¹
Rat
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Up to 20% of dose is metabolised in the liver and is excreted unchanged in the urine and faeces
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
May cause nausea and vomiting May cause disturbance in the production of blood cells Mmay cause hyperkalaemia
No information available
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Not listed (Not listed)
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trimethoprim
trimethoprime
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trimetoprima
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trimetoprim
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Record last updated:
03/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242