Selamectin |
![]() Last updated: 21/06/2023 |
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(Also known as: selamectine) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A drug most commonly used for preventing heartworms and controlling fleas in dogs and cats but is also used for treating ear mites and other parasites | |
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Dogs, Cats, Ferrets, Rodents |
Chemical structure |
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Salamectin is a chiral molecule | |
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C₄₃H₆₃NO₁₁ | |
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CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)O)OC)C)OC1C7CCCCC7 | |
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C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7 | |
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AFJYYKSVHJGXSN-XHKIUTQPSA-N | |
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InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1 | |
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Yes |
General status |
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Antiparasitic, Insecticide, Antihelminthic, Acaricide | |
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Avermectin | |
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Synthetic | |
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Disables parasites by replacing glutamate in their muscle synapses. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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[Glutamate receptor 1, antagonist] | |
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165108-07-6 | |
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220119-17-5 | |
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QP54AA05 | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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No | |
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No data | |
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769.96 | |
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(10E,14E,16E,21Z)-(1R,4S,5'S,6R,6'S,8R,12S,13S,20R,21R,24S)-6'-cyclohexyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(tetrahydropyran)-12-yl 2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranoside | |
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(5Z,25S)-25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a | |
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Formulations |
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Stronghold Spot on Solution | Pfizer Ltd | EU Centralised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Revolution | Pfizer Ltd | No UK authorisation for use with animals | Not applicable | |||||||
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Usually supplied as a liquid and applied topically |
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0.435 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.41 X 1003 | Calculated | - | |||||||
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3.15 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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2.0 X 10-11 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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Degradation |
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Soil adsorption and mobility |
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- | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-mobile | |||||||
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213546 | ||||||||||
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EU Veterinary document Koc range 24459 to 402633 mL g⁻¹ | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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abamectin (Ref: MK 936) | - | - | - | - |
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Terrestrial ecotoxicology |
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> 1600 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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266 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
Low | ||||||||
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0.000026 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
High | ||||||||
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0.028 | E3 E = Manufacturers safety data sheets Mysidopsis bahia3 = Unverified data of known source |
High | ||||||||
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28 | E3 E = Manufacturers safety data sheets Red algae3 = Unverified data of known source |
Low | ||||||||
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> 766 | E3 E = Manufacturers safety data sheets Selenastrum capricornutum3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1600 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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In dogs: majority excreted in shed hair and faeces, remained identified in urine and house/bedding rinse water | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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IMDG Transport Hazard Class 9 | |||
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Not listed (Not listed) | |||
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UN3077 | |||
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Packaging Group II (moderate danger) | |||
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selamectin | ||
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selamectine | ||
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Selamectin | ||
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selamectin | ||
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selamectin | ||
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selamectina | ||
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selamectin | ||
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selamektyna | ||
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selamectin | ||
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selamectin | ||
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Record last updated: | 21/06/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |